Factors associated with time to disability progression in patients with multiple sclerosis

Authors

DOI:

https://doi.org/10.17843/rpmesp.2022.394.11433

Keywords:

multiple sclerosis, Multivariate Analysis, disability evaluations

Abstract

Objectives. To determine the sociodemographic, clinical and radiological factors associated with time to disability progression in patients with multiple sclerosis (MS). Materials and methods. Cross-sectional descriptive study with an analytical component, based on clinical records of patients at the Neurological Institute of Colombia, between 2013 and 2021. Progression to disability in MS patients was defined as the time to an increase of at least 0.5 points in the EDSS (Expanded Disability Status Scale) score, sustained
for at least six months. A Cox regression model was used to estimate the survival function and Hazard Ratios (HR) with their 95% confidence intervals (95% CI). Results. We included 216 patients, of whom 25% progressed to disability, median survival was 78 months (95% CI: 70-83), active lesions (HR = 1.94; 95% CI: 1.10-3.44), cerebellar complications (HR = 2.03; 95% CI: 0. 99-4.16), being male (HR = 2.5; 95% CI: 1.32-4.73), and having neurological diseases (HR = 2.18; 95% CI: 1.03-4.61) were associated as risk factors. While relapsing remitting MS (HR = 0.63; 95% CI: 0.31-1.26) and age at diagnosis less than 40
years (HR = 0.96; 95% CI: 0.53-1.76) were associated as protective factors. Conclusions. Progression is affected by many factors, and there is no single independent factor.

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Published

2022-12-26

Issue

Section

Original Article

How to Cite

1.
Arteaga-Noriega A, Castro-Álvarez JF, Benjumea-Bedoya D, Gutiérrez-Vargas J, Segura-Cardona A, González-Gómez D, et al. Factors associated with time to disability progression in patients with multiple sclerosis. Rev Peru Med Exp Salud Publica [Internet]. 2022 Dec. 26 [cited 2024 Dec. 10];39(4):442-49. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/11433