Metabolic syndrome after liver transplant in patients at the Specialized Center San Vicente Fundación, Rionegro, Antioquia, Colombia, 2013-2017

Authors

DOI:

https://doi.org/10.17843/rpmesp.2022.394.11992

Keywords:

Metabolic Syndrome, Liver Transplant, Colombia

Abstract

The medical records of all liver transplant patients attended at the Centro Especializado San Vicente Fundación between January 2013 and June 2017 were reviewed in order to determine the frequency of post-transplant metabolic syndrome (MetS). We collected sociodemographic data, pathological history, toxicological history, complications, and ATP III criteria in a validated instrument. The statistical analysis was carried out with OpenEpi 3.01; p<0.05 was considered as statistically significant. Of the 102 reviewed medical records, 73 met the inclusion criteria (no MetS diagnosis prior to transplant and complete information for the instrument) and were analyzed. Most patients were male (59%), older adults (64%) and married (62%). The frequency of MetS after liver transplant was 66%. The association between MetS and history of hypertension and diabetes was significant. We confirmed that MS is a frequent complication in liver transplant recipients and that history of hypertension and diabetes are the most frequent associated factors.

Downloads

Download data is not yet available.

References

International Report on Organ Donation and Transplantation Activities. Executive summary 2017 [Internet]. Global Observatory on

Donation and Transplantation. 2019 [citado el 24 de junio de 2022]. Disponible en: http://www.transplant-observatory.org/.

Informe Anual Red de Donación y Trasplantes Colombia [Internet]. Instituto Nacional de Salud, Gobierno de Colombia. 2017 [citado el 24 de junio de 2022]. Disponible en: https://www.ins.gov.co/Direcciones/RedesSaludPublica/DonacionOrganosYTejidos/Estadisticas/INFORME%20ANUAL%20RED%20DE%20DONACION%20Y%20TRASPLANTES%202017.pdf.

Jiménez-Pérez M, González-Grande R, Omonte Guzmán E, Amo Trillo V, Rodrigo López JM. Metabolic complications in liver transplant recipients. World J Gastroenterol. 2016;22(28):6416-23. doi: 10.3748/wjg.v22.i28.6416.

Ramírez-López LX, Aguilera AM, Rubio CM, Aguilar-Mateus ÁM. Síndrome metabólico: una revisión de criterios internacionales. Revista Colombiana de Cardiología. 2021;28:60-6.

Lizarzaburu Robles JC. Síndrome metabólico: concepto y aplicación práctica. Anales de la Facultad de Medicina. 2013;74:315-20.

Vida Perez L, Montero Alvarez JL, Poyato Gonzalez A, Briceño Delgado J, Costan Rodero G, Fraga Rivas E, et al. Prevalence and Predictors of Metabolic Syndrome After Liver Transplantation. Transplant Proc. 2016;48(7):2519-24. doi: 10.1016/j.transproceed.2016.08.029.

Plotogea O, Ilie M, Sandru V, Chiotoroiu A, Bratu O, Diaconu C. Cardiovascular and Metabolic Consequences of Liver Transplantation: A Review. Medicina (Kaunas). 2019;55(8). doi: 10.3390/medicina55080489.

Chang AL, Cortez AR, Bondoc A, Schauer DP, Fitch A, Shah SA, et al. Metabolic syndrome in liver transplantation: A preoperative and postoperative concern. Surgery. 2016;160(4):1111-7. doi: 10.1016/j.surg.2016.06.015.

Zheng J, Wang WL. Risk factors of metabolic syndrome after liver transplantation. Hepatobiliary Pancreat Dis Int. 2015;14(6):582-7. doi: 10.1016/s1499-3872(15)60037-6.

Thoefner LB, Rostved AA, Pommergaard HC, Rasmussen A. Risk factors for metabolic syndrome after liver transplantation: A systematic review and meta-analysis. Transplant Rev (Orlando). 2018;32(1):69-77. doi: 10.1016/j.trre.2017.03.004.

Sprinzl MF, Weinmann A, Lohse N, Tönissen H, Koch S, Schattenberg J, et al. Metabolic syndrome and its association with fatty liver disease after orthotopic liver transplantation. Transpl Int. 2013;26(1):67-74. doi: 10.1111/j.1432-2277.2012.01576.x.

Couto CA, Gelape CL, Doycheva IB, Kish JK, Martin P, Levy C. Ethnicity predicts metabolic syndrome after liver transplant. Hepatol Int. 2013;7(2):741-8. doi: 10.1007/s12072-012-9416-x

Laish I, Braun M, Mor E, Sulkes J, Harif Y, Ben Ari Z. Metabolic syndrome in liver transplant recipients: prevalence, risk factors, and association with cardiovascular events. Liver Transpl. 2011;17(1):15-22. doi: 10.1002/lt.22198.

Lunati ME, Grancini V, Agnelli F, Gatti S, Masserini B, Zimbalatti D, et al. Metabolic syndrome after liver transplantation: short-term prevalence and pre- and post-operative risk factors. Dig Liver Dis. 2013;45(10):833-9. doi: 10.1016/j.dld.2013.03.009.

Ruiz-Rebollo ML, Sánchez-Antolín G, García-Pajares F, Fernández-Orcajo P, González-Sagrado M, Cítores-Pascual MA, et al. Risk of development of the metabolic syndrome after orthotopic liver transplantation. Transplant Proc. 2010;42(2):663-5. doi: 10.1016/j.transproceed.2010.02.018.

Tan HL, Lim KB, Iyer SG, Chang SK, Madhavan K, Kow AW. Metabolic syndrome after a liver transplantation in an Asian population. HPB (Oxford). 2015;17(8):713-22. doi: 10.1111/hpb.12435.

Bianchi G, Marchesini G, Marzocchi R, Pinna AD, Zoli M. Metabolic syndrome in liver transplantation: relation to etiology and immunosuppression. Liver Transpl. 2008;14(11):1648-54. doi: 10.1002/lt.21588

Ladevaia M, Giusto M, Giannelli V, Lai Q, Rossi M, Berloco P, et al. Metabolic syndrome and cardiovascular risk after liver transplantation: a single-center experience. Transplant Proc. 2012;44(7):2005-6. doi: 10.1016/j.transproceed.2012.06.022.

Kallwitz ER, Loy V, Mettu P, Von Roenn N, Berkes J, Cotler SJ. Physical activity and metabolic syndrome in liver transplant recipients. Liver Transpl. 2013;19(10):1125-31. doi: 10.1002/lt.23710.

Published

2022-12-22

Issue

Section

Brief Report

How to Cite

1.
Salazar-Flórez JE, Arango-Flórez EM, Morales-Toro M, Rojas-Copete A del M, Leal-Castillo DA, Toro-Rendón LG. Metabolic syndrome after liver transplant in patients at the Specialized Center San Vicente Fundación, Rionegro, Antioquia, Colombia, 2013-2017. Rev Peru Med Exp Salud Publica [Internet]. 2022 Dec. 22 [cited 2024 Dec. 10];39(4):474-9. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/11992