Invasive pneumococcal disease in patients from a pediatric hospital in Peru, 2017-2020

Authors

DOI:

https://doi.org/10.17843/rpmesp.2022.394.12054

Keywords:

Streptococcus pneumoniae, Pneumococcal Vaccines, Child, Hyperuricemia

Abstract

This study aimed to describe the clinical characteristics, serotypes, and antibiotic susceptibility in patients with invasive pneumococcal disease (IPD). The medical records of patients with IPD who were hospitalized at the Instituto Nacional de Salud del Niño-Breña (Lima, Peru) were reviewed. We evaluated 29 patients. The median age was 1.9 years (interquartile range: 1 to 4 years). Of the sample, 51.7% were women and the most frequent clinical form of IPD was bacteremia in 18 (62.1%) patients; 65.5% had a complete vaccination schedule, according to the Peruvian Ministry of Health. Germ isolation was performed from blood samples in 82.8% of patients. Antibiotic resistance to erythromycin (55.2%) was the most frequent, followed by
resistance to trimethoprim-sulfamethoxazole (48.3%) and penicillin (24.1%). The isolated serotypes were 6C, 19A, 23A and 24F. One patient died of meningitis. In conclusion, IPD was more frequent in children aged one to five years and the most frequent clinical form was bacteremia. Five serotypes reported in previous studies were found to be resistant to penicillin and erythromycin.

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References

Weiser JN, Ferreira DM, Paton JC. Streptococcus pneumoniae: transmission, colonization and invasion. Nat Rev Microbiol. 2018;16(6):355-67. doi: 10.1038/s41579-018-0001-8.

Wahl B, O’Brien KL, Greenbaum A, Majumder A, Liu L, Chu Y, et al. Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000–15. Lancet Glob Health. 2018;6(7):e744-57. doi: 10.1016/S2214-109X(18)30247-X.

Cherazard R, Epstein M, Doan TL, Salim T, Bharti S, Smith MA. Antimicrobial Resistant Streptococcus pneumoniae: Prevalence, Mechanisms, and Clinical Implications. Am J Ther. 2017;24(3):e361-9. doi: 10.1097/MJT.0000000000000551.

Narváez PO, Gomez-Duque S, Alarcon JE, Ramirez-Valbuena PC, Serrano-Mayorga CC, Lozada-Arcinegas J, et al. Invasive pneumococcal disease burden in hospitalized adults in Bogota, Colombia. BMC Infect Dis. 2021;21(1):1059. doi: 10.1186/s12879-021-6769-2.

Castro JD, Siccha SM, Egoavil M, Chaparro E, Hernandez R, Silva W, et al. Resistencia antibiótica y distribución de serotipos en cepas neumocócicas invasivas en adultos hospitalizados en Lima, Perú. Rev Peru Med Exp Salud Pública. 2017;34(4):633-41. doi: 10.17843/rpmesp.2017.344.2884

Luna-Muschi A, Castillo-Tokumori F, Deza MP, Mercado EH, Egoavil M, Sedano K, et al. Invasive pneumococcal disease in hospitalised children from Lima, Peru before and after introduction of the 7-valent conjugated vaccine. Epidemiol Infect. 2019;147:e91. doi: 10.1017/S0950268819000037.

Atamari-Anahui N, Ccorahua-Rios MS, Rodriguez-Camino MC, Santander-Cahuantico AC, Pacheco-Mendoza J. Bibliometric Analysis of Scientific Production in Scopus by the Instituto Nacional de Salud Del Niño-Breña, Peru, 2010–2019. J Hosp Librariansh. 2022;22(2):108-20. doi: 10.1080/15323269.2022.2054601.

Ochoa TJ, Egoavil M, Castillo ME, Reyes I, Chaparro E, Silva W, et al. Invasive pneumococcal diseases among hospitalized children in Lima, Peru. Rev Panam Salud Pública. 2010;28(2):121-7. doi: 10.1590/S1020-49892010000800008.

World Health Organization. Manual for the laboratory identification and antimicrobial susceptibility testing of bacterial pathogens of public health importance in the developing world : Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae, Neisseria gonorrhoea, Salmonella serotype Typhi, Shigella, and Vibrio cholerae [Internet]. World Health Organization; 2003 [citado 24 de agosto de 2022]. Report No.: WHO/CDS/CSR/RMD/2003.6. Disponible en: https://apps.who.int/iris/handle/10665/68554.

Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. 27th Edition [Internet]. Wayne, PA: Clinical and Laboratory Standards Institute: CLSI supplement M100; 2017 [citado 27 agosto de 2022]. Disponible en: https://clsi.org/media/1469/m100s27_sample.pdf.

Torres N, Velásquez R, Mercado EH, Egoavil M, Horna G, Mejía L, et al. Resistencia antibiótica de streptococcus pneumoniae en portadores nasofaríngeos sanos de siete regiones del Perú. Rev Peru Med Exp Salud Publica [Internet]. 2013 [citado 27 agosto de 2022];30(4):575-82. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1726-46342013000400006.

Agudelo CI, Castañeda E, Corso A, Regueira M, Brandileone MC de C, Brandão AP, et al. [Resistance to non-beta-lactam antibiotics in the clinical isolates of Streptococcus pneumoniae of children in Latin America. SIREVA II, 2000-2005]. Rev Panam Salud Publica Pan Am J Public Health. 2009;25(4):305-13. doi: 10.1590/s1020-49892009000400004.

Gonzales BE, Mercado EH, Pinedo-Bardales M, Hinostroza N, Campos F, Chaparro E, et al. Increase of Macrolide-Resistance in Streptococcus pneumoniae Strains After the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine in Lima, Peru. Front Cell Infect Microbiol. 2022;12:866186. doi: 10.3389/fcimb.2022.866186.

Mercado EH, Egoavil M, Horna SG, Torres N, Velásquez R, Castillo ME, et al. Serotipos de neumococo en niños portadores antes de la vacunación antineumocócica en el Perú. Rev Peru Med Exp Salud Publica [Internet]. 2012 [citado 27 agosto de 2022];29(1):53-60. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1726-46342012000100008&lng=es&nrm=iso&tlng=es.

Davalos L, Terrazas Y, Quintana A, Egoavil M, Sedano K, Castillo ME, et al. Características epidemiológicas, clínicas y bacteriológicas de meningitis neumocócica en pacientes pediátricos de Lima, Perú. Rev Peru Med Exp Salud Publica. 2016;33(3):425-31. doi: 10.17843/rpmesp.2016.333.2349.

Fernández V JP, Goecke H C, von Borries C, Tapia R N, Santolaya de P ME. Incidencia de egresos por neumonía en niños menores de 24 meses antes y después de la implementación de la vacuna conjugada antineumocócica 10-valente en el Programa Nacional de Inmunizaciones de Chile. Rev Chil Pediatría. 2015;86(3):168-72. doi: 10.1016/j.rchipe.2015.04.026.

Atamari-Anahui N, Conto-Palomino NM, Pereira-Victorio CJ. Actividades de inmunización en el contexto de la pandemia por la COVID-19 en Latinoamérica. Rev Peru Med Exp Salud Publica. 2020;37(4):773-5. doi: 10.17843/rpmesp.2020.374.5758.

Published

2022-12-19

Issue

Section

Brief Report

How to Cite

1.
Marín-Portocarrero JG, Quispe-Sanchez A, Charca-Rodriguez F de M, Atamari-Anahui N. Invasive pneumococcal disease in patients from a pediatric hospital in Peru, 2017-2020. Rev Peru Med Exp Salud Publica [Internet]. 2022 Dec. 19 [cited 2024 Oct. 15];39(4):469-73. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/12054

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