Meningitis and neurosensory hypoacousia due to Rickettsia sp. in Peru: case report

Authors

DOI:

https://doi.org/10.17843/rpmesp.2024.413.13393

Keywords:

Meningitis, Rickettsia Infections, Hearing Loss, Sensorineural

Abstract

We present the case of a young female health worker, resident in a high Andean region of Peru, with recent exposure to farm animals and arthropods, who developed acute febrile undifferentiated syndrome, severe thrombocytopenia and pulmonary and abdominal extravasation. Subsequently, the patient developed  meningitis and early onset bilateral neurosensorial hypoacusis and showed reactive serology to acute  infection by Rickettsia sp. Epidemiological and clinical considerations in the differential diagnosis for early  management are discussed.

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References

Tomassone L, Portillo A, Nováková M, de Sousa R, Oteo JA. Neglected aspects of tick-borne rickettsioses. Parasit Vectors. 2018;11(1):263. doi: 10.1186/s13071-018-2856-y.

Sekeyová Z, Danchenko M, Filipčík P, Fournier PE. Rickettsial infections of the central nervous system. PLOS NTDs. 2019;13(8):e0007469. doi: 10.1371/journal.pntd.0007469.

Forshey BM, Stewart A, Morrison AC, Gálvez H, Rocha C, Astete H, et al. Epidemiology of spotted fever group and typhus group rickettsial infection in the Amazon basin of Peru. Am J Trop Med Hyg. 2010;82(4):683-90. doi: 10.4269/ajtmh.2010.09-0355.

Palacios-Salvatierra R, Anaya-Ramírez E, Juscamayta-López J, Cáceres-Rey O, Mendoza-Uribe L, Mosquera-Visaloth P, et al. Perfil

epidemiológico y molecular de Rickettsiosis en localidades de frontera peruana. Rev Perú Med Exp Salud Publica. 2017;34(1):76. doi: 10.17843/rpmesp.2017.341.2769.

Salmon-Mulanovich G, Simons MP, Flores-Mendoza C, Loyola S, Silva M, Kasper M, et al. Seroprevalence and risk factors for rickettsia and leptospira infection in Four Ecologically Distinct Regions of Peru. Am J Trop Med Hyg. 2019;100(6):1391-400. doi: 10.4269/ajtmh.18-0029.

Kocher C, Morrison AC, Leguia M, Loyola S, Castillo RM, Galvez HA, et al. Rickettsial Disease in the Peruvian Amazon Basin. PLOS NTDs.

;10(7). doi: 10.1371/journal.pntd.0004843.

Palacios-Salvatierra R, Cáceres-Rey O, Vásquez-Domínguez A, Mosquera-Visaloth P, Anaya-Ramírez E. Especies rickettsiales en casos humanos con síndrome febril agudo inespecífico en Perú. Rev Perú Med Exp Salud Publica. 2018;35(4):630. doi: 10.17843/rpmesp.2018.354.3646.

Abarca K, Oteo JA. Clinical approach and main tick-borne rickettsiosis present in latin america. Rev Chil Infectol. 2014;31(5):569-76.

Faccini-Martínez ÁA, Forero-Becerra EG, Cortés-Vecino JA, Polo-Teran LJ, Jácome JH, Vargas JJ, et al. Caso probable de fiebre manchada (Rickettsia felis) transmitida por pulgas. Biomedica. 2013;33(SUPPL. 1):9-13.

Mostorino E Rosa, Anaya R Elizabeth, Mendoza U Leonardo RAA. Identificación de una nueva área de infección por rickettsias del grupo typhi: estudio de un brote de tifus en Huánuco. Rev Peru Med Exp Salud Publica. 2003;20(1):15-21.

Oteo JA, Nava S, de Sousa R, Mattar S, Venzal JM, Abarca K, et al. Guías latinoamericanas de la RIICER para el diagnóstico de las rickettsiosis transmitidas por garrapatas. Rev Chil Infectol. 2014;31(1):54-65. doi: 10.4067/S0716-10182014000100009.

Botelho-Nevers E. Rickettsiosis y ehrlichiosis. EMC Dermatol. 2014;48(3):1-10. doi: 10.1016/S1761-2896(14)68404-1.

Ministerio de Salud. Leptospirosis-Reporte Semana Epidemiológica Número 18. Centro Nacional de Epidemiologia Prevencion y Control de Enfermedades; 2020. Disponible en: https://www.dge.gob.pe/portal/docs/vigilancia/sala/2020/SE18/leptospirosis.pdf.

Tsiachris D, Deutsch M, Vassilopoulos D, Zafiropoulou R, Archimandritis AJ. Sensorineural hearing loss complicating severe rickettsial

diseases: Report of two cases. Journal of Infection. 2008;56(1):74-6. doi: 10.1016/j.jinf.2007.10.002.

Kang JI, Kim DM, Lee J. Acute sensorineural hearing loss and severe otalgia due to scrub typhus. BMC Infect Dis. 2009;9:173. doi:

1186/1471-2334-9-173.

Rossio R, Conalbi V, Castagna V, Recalcati S, Torri A, Coen M, et al. Mediterranean spotted fever and hearing impairment: A rare complication. Int J Infecto Dis. 2015;35:34-6. doi: 10.1016/j.ijid.2015.04.005.

Rodríguez-Álvarez M. Aminoglucósidos. Enferm Infecc Microbiol. 2002;22(1):20-30.

Quintero Noa Julianis, Hernández Cordero María del Carmen, de León Ojeda Norma Elena, Meléndez Quintero Loraine. Ototoxicidad

y factores predisponentes. Rev Cubana Pediatr. 2018 Mar; 90(1): 111-131. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312018000100011&lng=es.

Biggs HM. Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis — United States. MMWR Recomm Rep. 2016; 13;65(2):1-44. doi: 10.15585/mmwr.rr6502a1.

Blanton LS. The Rickettsioses: A Practical Update. Infect Dis Clin North Am. 2019;33(1):213-29. doi:10.1016/j.idc.2018.10.010.

Varghese GM., Dayanand D, Gunasekaran K, Kundu D, Wyawahare M, Sharma N, et al. Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus. N Engl J Med. 2023;388(9):792-803. doi: 10.1056/NEJMoa2208449.

Published

2024-09-03

Issue

Section

Case Report

How to Cite

1.
Agramonte MJ, Vilcarromero S, Núñez-Melgar Z. Meningitis and neurosensory hypoacousia due to Rickettsia sp. in Peru: case report. Rev Peru Med Exp Salud Publica [Internet]. 2024 Sep. 3 [cited 2024 Dec. 21];41(3):316-20. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/13393

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