Meningitis due to Cryptococcus gattii in an immunosuppressed patient in a hospital in the Peruvian Amazon: case report
DOI:
https://doi.org/10.17843/rpmesp.2025.422.14195Keywords:
Cryptococcosis, immunocompromised host, amphotericin BAbstract
We report a case of Cryptococcus gattii meningitis in a patient with HIV in the Peruvian Amazon. A 36-year-old male patient presented severe neurological symptoms and was diagnosed by cerebrospinal fluid culture. Although liposomal amphotericin B and flucytosine are considered the standard antifungal therapy, due to lack of resources, an alternating regimen of Amphotericin B deoxycholate and Fluconazole was used, and even with this, the treatment faced challenges due to the persistence of the microorganism. This case highlights the importance of considering C. gattii in the differential diagnosis of cryptococcal meningitis in immunocompromised patients, even in areas where the prevalence of this pathogen is low. Treatment effectiveness and patient survival highlight the need for diagnostic and therapeutic strategies adapted to resource-limited settings.
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Copyright (c) 2025 Angel A. Moreno-Soto, Rodrigo J. Cardenas-Golac, Marco F. Paredes-Obando, Jhosephi J. Vasquez-Ascate, Jorge Sibina-Vela, Edgar A. Ramírez-García, Juan C. Celis-Salinas, Wilfredo M. Casapia-Morales
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