Effect of levonorgestrel in the ovulation, endometrium, and spermatozoa for emergency oral contraception
DOI:
https://doi.org/10.17843/rpmesp.2010.272.1468Keywords:
Postcoital contraception, Levonorgestrel, Endometrium, Ovulation, SpermatozoaAbstract
There is wide controversy about the mechanism of action of the levonorgestrel used for emergency oral contraception, and many organizations, both scientific as well as from the civil society, show their discrepancy with its use, due to its possible action as an abortion- inducer. In order to evaluate the scientific evidence available on the mechanisms of action of the levonorgestrel used for emergency oral contraception (EOC), a systematic revision was performed in the Medline and Cochrane library databases. We found 444 articles. After reviewing the abstracts, we selected 22 articles, whose complete texts were evaluated. We found that the main mechanism of action of the levonorgestrel, given at the doses recommended for EOC, is the inhibition or retardation of the ovulation, it doesn’t affect the spermatozoa in their migration or egg-penetration capacities. No morphological or molecular alterations in the endometrium that could interfere with the implantation of the fertilized egg have been demonstrated. There is no actual scientific evidence available supporting that the use of levonorgestrel for EOC is abortive.Downloads
Download data is not yet available.
Downloads
Published
2010-06-25
Issue
Section
Review
How to Cite
1.
Suárez VJ, Zavala R, Ureta JM, Hijar G, Lucero J, Pachas P. Effect of levonorgestrel in the ovulation, endometrium, and spermatozoa for emergency oral contraception. Rev Peru Med Exp Salud Publica [Internet]. 2010 Jun. 25 [cited 2024 Dec. 1];27(2). Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/1468