Distribución de serotipos, biotipo y sensibilidad antibiótica de Haemophilus influenzae en niños portadores nasofaríngeos en Lima, Perú

Brayan E. Gonzales; Maria Pinedo-Bardales; Marcela  Lopez-Briceño; Edison A. Rivera-Fernandez; David Durand Vara; Erik H. Mercado; Faviola Valdivia; Theresa J. Ochoa

doi:10.17843/rpmesp.2025.424.14767

Authors

Brayan E. Gonzales Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Perú. https://orcid.org/0000-0002-3059-6736
Maria Pinedo-Bardales Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Perú https://orcid.org/0000-0002-0169-5620
Marcela Lopez-Briceño Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru https://orcid.org/0000-0001-9163-6239
Edison A. Rivera-Fernandez Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru https://orcid.org/0000-0002-4117-3210
David Durand Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru https://orcid.org/0000-0002-9296-2850
Erik H. Mercado Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru https://orcid.org/0000-0003-0899-521X
Faviola Valdivia Laboratorio de Infecciones Respiratorias Agudas, Centro Nacional de Salud Pública, Instituto Nacional de Salud, Lima, Peru https://orcid.org/0000-0001-8347-6853
Theresa J. Ochoa Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru. Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru https://orcid.org/0000-0002-3227-3906

DOI:

https://doi.org/10.17843/rpmesp.2025.424.14767

Keywords:

Hib Vaccine, Haemophilus influenzae, Colonization, Serotypes, Biotypes

Abstract

After the introduction of the Hib (Haemophilus influenzae type b) vaccine, invasive infection caused by
this bacterium markedly decreased; however, concern increased regarding the other typable and non-typable
strains (NTHi). Prior colonization with this pathogen can become a source of invasive infection. This study aimed to determine colonization by H. influenzae in 888 healthy children under 24 months of age. Colonization was 4.1% (37 samples) using molecular methods (all NTHi) and 1.1% (10 isolates) by culture (8/10 biotype I and 2/10 biotype IV). A history of prematurity was associated with higher colonization in multivariate analysis. Of the isolates, 9/10 were resistant to sulfamethoxazole/trimethoprim, 3/10 to ampicillin and cefuroxime, 2/10 to azithromycin, and no resistance to ceftriaxone was observed. Understanding the carriage status of H. influenzae and local resistance patterns is useful for empirical antibiotic therapy in invasive infections where this bacterium is suspected.

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