Fulminant myocarditis associated with severe dengue in a young patient from the Peruvian Amazon: case report and literature review

Authors

DOI:

https://doi.org/10.17843/rpmesp.2025.424.14881

Keywords:

Dengue, Heart, Cardiac Arrhythmias, Severe Dengue

Abstract

Dengue is an endemic viral infection of tropical regions that can present with clinical presentations ranging from mild forms to severe complications. Dengue-associated myocarditis, although uncommon, is a potentially fatal complication that should be suspected in febrile patients from endemic areas presenting with signs of  cardiovascular dysfunction. We present the case of a 21-year-old male, resident in the Peruvian Amazon, who developed acute heart failure and refractory cardiogenic shock secondary to dengue myocarditis, with a fatal outcome on the third day of hospitalization. This case highlights the importance of early recognition of myocardial involvement and timely cardiovascular monitoring to reduce mortality associated with this infection.

Downloads

Download data is not yet available.

References

WHO. Dengue Guidelines for Diagnosis, Treatment, Prevention and Control. Geneva: WHO Press; 2009.

Sandeep M, Padhi BK, Yella SST, Sruthi KG, Venkatesan RG, Sasanka KSB, et al. Myocarditis manifestations in dengue cases: a systematic review and meta-analysis. J Infect Public Health. 2023;16(11):1761-1768. doi: 10.1016/j.jiph.2023.08.005.

Simmons CP, Farrar JJ, Nguyen VV, Wills B. Dengue. N Engl J Med. 2012;366(15):1423-1432. doi: 10.1056/NEJMra1110265.

Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature.

;496(7446):504-507. doi: 10.1038/nature12060.

Guzman MG, Harris E. Dengue. Lancet. 2015;385(9966):453-465. doi: 10.1016/S0140-6736(14)60572-9.

Yacoub S, Wertheim H, Simmons CP, et al. Nat Rev Cardiol. 2014.

Miranda CH, Borges MC, Matsuno AK, Vilar FC, Gali LG, Volpe GJ, et al. Evaluation of cardiac involvement during dengue viral infection. Clin Infect Dis. 2013;57(6):812-9. doi: 10.1093/cid/cit403.

Lee IK, Liu JW, Yang KD. Clinical characteristics and risk factors for concurrent bacteremia in adults with dengue hemorrhagic fever. Am J Trop Med Hyg. 2005;72(2):221-6.

Datta G, Mitra P. A study on cardiac manifestations of dengue fever. J Assoc Physicians India. 2019;67(6):14-16.

Mansanguan C, Hanboonkunupakarn B, Muangnoicharoen S, Huntrup A, Poolcharoen A, Mansanguan S, et al. Cardiac evaluation in

adults with dengue virus infection by serial echocardiography. BMC Infect Dis. 2021;21:940. doi: 10.1186/s12879-021-06639-x.

Yacoub S, Wertheim H, Simmons CP. Cardiovascular manifestations of the emerging dengue pandemic. Nat Rev Cardiol. 2014;11(6):335-345. doi: 10.1038/nrcardio.2014.40.

Cristodulo R, Luoma-Overstreet G, Leite F, Vaca M, Navia M, Durán G, et al. Dengue Myocarditis: A Case Report and Major Review. Glob Heart. 2023;18(1):41. doi: 10.5334/gh.1254.

Pramudyo M, Putra ICS, Iqbal M, Prameswari HS, Karwiky G, Dewi TI, et al. Clinically suspected acute right ventricular fulminant dengue myocarditis masquerading with dual lethal arrhythmias: a case report. J Med Case Reports. 18(1):554. doi: 10.1186/s13256-024-04792-w.

Baqi A, Ur Rehman F, Memon PS, Omair SF. Prevalence and Outcomes of Myocarditis in Dengue-Infected Patients Admitted to a

Tertiary Care Hospital of Low-Middle Income Country. Global Heart. 2022;17(1):44. doi: 10.5334/gh.1129.

Bhatt M, Soneja M, Farooqui FA, Singla P, Vikram NK, Biswas A, et al. Myocarditis in admitted patients with dengue fever. Infection.

;48(6):899-903. doi: 10.1007/s15010-020-01500-w.

Carta KG, Britto IM, Mujica IM. Compromiso cardiovascular del dengue. Rev Fed Arg Cardiol. 2024;53(2):54-6. doi: 10.63600/vqswjk16.

Pérez Valega L, Mullins T, Olivera L, Caravagio S. Dengue Fulminant Myocarditis with ECG Brugada Type 1 Pattern. Rev Argent Cardiol.

;92(2):163-5. doi: 10.7775/rac.es.v92.i2.20764.

Dirección Regional de Salud – Loreto. Alerta ante el incremento de casos de dengue y fallecidos. A.E. 02 – Dengue – 2025. Mayo 2025. p. 2.

Silva JS, Trindade AT, Pinto BF, Franco RPL, Faria YBD. Cardiac involvement in Dengue infection -a comprehensive review on pathophysiology, epidemiology, clinical manifestations, diagnosis and treatment. Braz J Health Rev. 2024;7(3):e69473. doi: 10.34119/bjhrv7n3-035.

Published

2025-12-03

Issue

Section

Case Report

How to Cite

1.
Ramirez García EA, Canchanya Olimar MJV, Montenegro Matute GF, Varela Meza EE, Mesones Ramirez V, Paucar Gonzales CE, et al. Fulminant myocarditis associated with severe dengue in a young patient from the Peruvian Amazon: case report and literature review. Rev Peru Med Exp Salud Publica [Internet]. 2025 Dec. 3 [cited 2026 Jun. 11];42(4):442-6. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/14881