Coinfección viral con SARS-CoV2 en pacientes peruanos hospitalizados durante los años 2020-2021

Carlos Augusto Yabar; Karolyn Vega-Chozo; Eduardo Miranda-Ulloa; Flor de María Peceros-Pelaez; Manuel Terrazas-Aranibar; Adolfo Marcelo; María Paquita García; María Elena López; Rubén Vásquez; Katia Zúñiga; Haydee Alvarado; Renso López-Liñán; Heriberto Arévalo; Nancy Rojas-Serrano

doi:10.17843/rpmesp.2026.431.15162

Authors

Carlos Augusto Yabar Unidad de Innovación y Soporte Diagnóstico, Instituto Nacional de Salud, Lima, Perú. Facultad de Medicina Humana, Universidad de San Martín de Porres, Lima, Perú. https://orcid.org/0000-0002-9607-5693
Karolyn Vega-Chozo Facultad de Ciencias Naturales y Matemáticas, Universidad Nacional Federico Villarreal, Lima, Perú https://orcid.org/0000-0001-8986-8081
Eduardo Miranda-Ulloa Laboratorio de Referencia Nacional de Virus de Transmisión Sexual, Instituto Nacional de Salud, Lima, Perú. https://orcid.org/0000-0001-5687-5437
Flor de María Peceros-Pelaez Laboratorio de Referencia Nacional de Virus de Transmisión Sexual, Instituto Nacional de Salud, Lima, Perú. https://orcid.org/0000-0003-4322-8868
Manuel Terrazas-Aranibar Laboratorio de Referencia Nacional de Virus de Transmisión Sexual, Instituto Nacional de Salud, Lima, Perú. https://orcid.org/0000-0002-1914-3509
Adolfo Marcelo Laboratorio de Referencia Nacional de Metaxénicas y Zoonosis Virales, Instituto Nacional de Salud, Lima, Perú https://orcid.org/0000-0002-0043-5819
María Paquita García Laboratorio de Referencia Nacional de Metaxénicas y Zoonosis Virales, Instituto Nacional de Salud, Lima, Perú https://orcid.org/0000-0002-2185-5038
María Elena López Hospital María Auxiliadora, Lima, Perú. https://orcid.org/0000-0002-9015-4788
Rubén Vásquez Hospital María Auxiliadora, Lima, Perú. https://orcid.org/0000-0001-7997-8172
Katia Zúñiga Hospital María Auxiliadora, Lima, Perú. https://orcid.org/0009-0007-2305-8095
Haydee Alvarado Hospital Regional de Loret, Loreto, Perú https://orcid.org/0000-0002-4769-5124
Renso López-Liñán Hospital Regional de Loreto, Loreto, Perú. Universidad Nacional de la Amazonia Peruana, Loreto, Perú. https://orcid.org/0000-0003-0253-6338
Heriberto Arévalo Laboratorio de Referencia Regional de Salud Pública de San Martín, San Martín, Perú. https://orcid.org/0000-0002-3252-6301
Nancy Rojas-Serrano Laboratorio de Referencia Nacional de Enfermedades Inmunoprevenibles, Instituto Nacional de Salud, Lima, Perú https://orcid.org/0000-0002-3194-8043

DOI:

https://doi.org/10.17843/rpmesp.2026.431.15162

Keywords:

Viral coinfection, SARS-CoV-2 infection, Severe Acute Respiratory Syndrome, Laboratory diagnosis

Abstract

This study aimed to identify SARS-CoV-2 coinfections with other viruses in patients with moderate to severe cases of COVID-19. A total of 98 patients from Lima, San Martín, and Loreto were recruited through convenience sampling. Nasopharyngeal swabs, blood samples, and urine samples were collected from these patients. Serological and molecular tests were used to analyze these samples and detect HTLV, HIV, hepatitis B, dengue, chikungunya, zika, and a panel of respiratory viruses (influenza A and B, rhinovirus, respiratory syncytial virus, metapneumovirus, and adenovirus). The results revealed two cases of coinfection (2/98; 2%): one involving SARS-CoV-2 and rhinovirus, and the other involving SARS-CoV-2 and HTLV-2. Both patients presented with pneumonia associated with SARS-CoV-2 but had a favorable outcome. The study concluded that the frequency of viral coinfection in patients with moderate and severe cases of COVID-19 from health facilities on the coast and in the jungle of Peru was low.

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