Acute toxicity of Xanthium spinosum leaves in BALB/C mice

Authors

  • Arturo Silvero-Isidre Facultad de Ciencias Médicas. Universidad Nacional de Asunción. Asunción, Paraguay.
  • Sergio Morínigo-Guayuán Facultad de Ciencias Médicas. Universidad Nacional de Asunción. Asunción, Paraguay.
  • Marcelo Mongelós-Cardozo Facultad de Ciencias Médicas. Universidad Nacional de Asunción. Asunción, Paraguay.
  • Aldo González-Ayala Departamento de Medicina Tropical. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Asunción. Asunción, Paraguay.
  • Susy Figueredo-Thiel Departamento de Patología. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Asunción. Asunción, Paraguay.

DOI:

https://doi.org/10.17843/rpmesp.2016.331.1888

Keywords:

Xanthium spinosum, Acute toxicity, Plants, medicinal

Abstract

The leaves of the Xanthium spinosum plant have been used culturally in Paraguay for their medicinal properties. Acute toxicity of mature leaf extract was evaluated. For the study, 35 Balb/c mice were selected and allocated into 7 groups, 6 test groups and 1 control group. The extract was prepared in concentrations of 6% and 9% (g/dL). The 6% concentration was administrated to 3 test groups and 9% concentration to the remaining 3 groups, with doses between 200 and 1000 mg/kg per mouse. After 14 days of observation, blood samples were taken for laboratory studies of urea and transaminases and organs were examined for pathological studies. There were increased levels of GOT and urea in the test groups compared to the control group. In conclusion, the consumption of mature leaf extract of Xanthium spinosum can cause hepatic damage.

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Published

2016-02-09

Issue

Section

Brief Report

How to Cite

1.
Silvero-Isidre A, Morínigo-Guayuán S, Mongelós-Cardozo M, González-Ayala A, Figueredo-Thiel S. Acute toxicity of Xanthium spinosum leaves in BALB/C mice. Rev Peru Med Exp Salud Publica [Internet]. 2016 Feb. 9 [cited 2024 May 29];33(1):113-9. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/1888

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