Gastroprotective and antisecretory effect of a phytochemical made from matico leaves (Piper aduncum)

Authors

  • Jorge Arroyo Instituto de Investigaciones Clínicas, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú. Laboratorio de Farmacología, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú. Químico farmacéutico
  • Pablo Bonilla Instituto de Ciencias Farmacéuticas y Recursos Naturales, Facultad de Farmacia y Bioquímica, Universidad Nacional Mayor de San Marcos. Lima, Perú. Químico farmacéutico.
  • Luis Moreno-Exebio Centro Nacional de Control de Calidad, Instituto Nacional de Salud. Lima, Perú. Químico farmacéutico.
  • Gerardo Ronceros Instituto de Investigaciones Clínicas, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú. Laboratorio Clínico, Hospital Dos de Mayo. Lima, Perú. médico cirujano.
  • Gloria Tomás Laboratorio de Productos Naturales, Facultad de Química e Ingeniería Química, Universidad Nacional Mayor de San Marcos. Lima, Perú. químico.
  • Juana Huamán Laboratorio de Productos Naturales, Facultad de Química e Ingeniería Química, Universidad Nacional Mayor de San Marcos. Lima, Perú. químico.
  • Ernesto Raez Instituto de Patología, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú. médico cirujano.
  • Mariano Quino Instituto de Investigaciones Clínicas, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú. Servicio de Gastroenterología, Hospital Nacional Dos de Mayo. Lima, Perú. médico cirujano.
  • Javier Rodriguez-Calzado Centro Nacional de Control de Calidad, Instituto Nacional de Salud. Lima, Perú. biólogo, bioestadístico.

DOI:

https://doi.org/10.17843/rpmesp.2013.304.240

Keywords:

Matico, Plants, medicinal, Phytotherapy, Plant extracts

Abstract

Objectives. To determine the gastroprotective and antisecretory effect of ethanol extract from matico leaves (Piper aduncum) in animal models. Materials and methods. To evaluate the gastroprotective effect, 220 mice of the Balb C57 strain were used. They were randomized in 22 groups of ten animals each, in which the formation of gastric ulcers was induced with indomethacin. Gastroprotection was determined by evaluating three aspects: inflammation, number of hemorrhagic shocks and number of ulcers. To evaluate the antisecretory effect, 64 white male Holtzman rats were used, which were randomized in eight groups of eight animals, one control and seven groups of treatment with one extract dose level and two phytochemical dose levels. Antisecretion was obtained through the pylorus ligation. Results. Regarding gastroprotection, dichloromethane, chloroform, hexane and methanol extracts decreased inflammation to over 66% (p<0,05). The ethanolic extract shows 100% activity in reducing the number of hemorrhagic bands (p<0,05). The chloroform extract shows antiulcer activity at 75% (p<0,05). In terms of antisecretion, the phytochemical in capsules containing the ethanolic extract achieved 72% reduction of the gastric secretion volume (p<0,01) and 104,3% (p<0,01) PH increase. Conclusions. In experimental conditions, ethanolic extracts, their fractions and phytochemicals have a gastroprotective effect in mice and antisecretory effect in rats.

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Published

2014-03-11

Issue

Section

Research Articles

How to Cite

1.
Arroyo J, Bonilla P, Moreno-Exebio L, Ronceros G, Tomás G, Huamán J, et al. Gastroprotective and antisecretory effect of a phytochemical made from matico leaves (Piper aduncum). Rev Peru Med Exp Salud Publica [Internet]. 2014 Mar. 11 [cited 2024 May 25];30(4). Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/240

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