Cathepsin L cysteine protease from Taenia solium: its biological role in the infection and potential use for the immunodiagnosis of neurocysticercosis

Authors

  • Nancy León Laboratorio de Bioinformática y Biología molecular, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia. Lima, Perú. Biólogo.
  • Carlos Padilla Laboratorio de Biotecnología y Biología molecular, Instituto Nacional de Salud (INS). Lima, Perú. Biólogo.
  • Mónica Pajuelo Laboratorio de Bioinformática y Biología molecular, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia. Lima, Perú. físico.
  • Patricia Sheen Laboratorio de Bioinformática y Biología molecular, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia. Lima, Perú. Biólogo. físico.
  • Mirko Zimic Laboratorio de Bioinformática y Biología molecular, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia. Lima, Perú. físico. PhD en control y prevención de enfermedades.

DOI:

https://doi.org/10.17843/rpmesp.2013.303.282

Keywords:

Cathepsin L, Taenia solium, Host-parasite interactions, Immunologic tests, Neurocysticercosis

Abstract

Taenia solium is a plane helminth responsible for taeniasis and human cysticercosis, the latter being the result of the consumption of infective eggs. Cysticerci can develop in different human tissues, often in the central nervous system, causing neurocysticercosis (NCC). For the diagnosis of NCC, an adequate interpretation of clinical data, neuroimaging results and serological tests are required. However, serological tests could be improved by developing candidate antigens able to increase their sensibility and specificity. In the last years, a series of surface and secretory proteins of T. solium essential for the parasite-host interaction have been described. One of these families is cathepsin L cysteine proteases, which have a predominant role in the development and survival of the parasite. They take part in the tissue invasion, immune response evasion, excystation and encystment of cysticercus. They are considered potential antigens for the immunodiagnosis of neurocysticercosis.

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Published

2014-03-11

Issue

Section

Review

How to Cite

1.
León N, Padilla C, Pajuelo M, Sheen P, Zimic M. Cathepsin L cysteine protease from Taenia solium: its biological role in the infection and potential use for the immunodiagnosis of neurocysticercosis. Rev Peru Med Exp Salud Publica [Internet]. 2014 Mar. 11 [cited 2024 Jun. 25];30(3). Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/282

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