Pneumococcal serotypes in carrier children prior to the introduction of anti-pneumococcal vaccines in Peru
DOI:
https://doi.org/10.17843/rpmesp.2012.291.308Keywords:
Streptococcus pneumoniae, Carriage, Serotyping, Child, PeruAbstract
Objectives. To determine the carriage rate and serotype distribution of Streptococcus pneumoniae in the nasopharynx of healthy children younger than 2 years prior to the universal use of the pneumococcal conjugate vaccines in Peru. Materials and methods. Between 2007 and 2009 we collected nasopharyngeal swab samples from 2,123 healthy children aged 2 to 24 months in the vaccination and healthy children consultation offices of pediatric hospitals and health centers in 7 cities in Peru: on the coast (Lima, Piura), highlands (Cusco, Abancay, Arequipa and Huancayo) and amazon basin (Iquitos). The pneumococcal strains were isolated and identified at the central laboratory of the project in Lima, and serotyped by Quellung reaction in the pneumococcal reference laboratory at the Center for Diseases Control and Prevention (CDC). Results. We found 27% (573/2123) of pneumococcal nasopharyngeal healthy carrier children. Among the 526 analyzed strains, we found 42 serotypes; the most common were: 19f (18.1%), 6B (14.3%); 23f (8.9%) and 14 (6.5%). Conclusions. The distribution of vaccine serotypes in the analyzed strains was of 50% for the serotypes present in the seven-valent vaccine, 50.2% for the serotypes present in the ten-valent vaccine and 57.2% for those present in the thirteen-valent vaccine.Downloads
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Published
2014-01-29
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Research Articles
How to Cite
1.
Mercado EH, Egoavil M, Horna SG, Torres N, Velásquez R, Castillo ME, et al. Pneumococcal serotypes in carrier children prior to the introduction of anti-pneumococcal vaccines in Peru. Rev Peru Med Exp Salud Publica [Internet]. 2014 Jan. 29 [cited 2024 Oct. 15];29(1). Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/308