Blastic plasmacytoid dendritic cell neoplasm variant acute leukemia: case report

Authors

  • Carlos Flores-Angulo Servicio de Hematología y Banco de Sangre, Hospital Universitario de Caracas (HUC). Caracas, Venezuela. Sección de Polimorfismos Genómicos, Instituto de Investigaciones Biomédicas “Dr. Francisco J. Triana Alonso”, Universidad de Carabobo, Maracay, Venezuela. Magíster en Ciencias Biomédicas; Médico hematólogo.
  • Zulay Chona Servicio de Hematología y Banco de Sangre, Hospital Universitario de Caracas (HUC). Caracas, Venezuela. Médico hematólogo
  • María A. Sánchez Servicio de Hematología y Banco de Sangre, Hospital Universitario de Caracas (HUC). Caracas, Venezuela. Médico hematólogo
  • Mauricio Salazar Servicio de Hematología y Banco de Sangre, Hospital Universitario de Caracas (HUC). Caracas, Venezuela. Médico hematólogo
  • Helen Hennig Servicio de Hematología y Banco de Sangre, Hospital Universitario de Caracas (HUC). Caracas, Venezuela. Médico hematólogo

DOI:

https://doi.org/10.17843/rpmesp.2019.362.3779

Keywords:

Blastic plasmacytoid dendritic cell neoplasm, hematologic malignancy, acute myeloid leukemia

Abstract

Blastic plasmacytoid dendritic cell blast neoplasm (BPDCN) is a rare and generally aggressive hematologic malignancy, requiring early recognition. Below is a description of the prolonged clinical course of a 60-year-old male patient with BPDCN from Venezuela, whose most relevant findings highlighted the presence of skin lesions, organomegaly, infiltration of the bone marrow and central nervous system. Systemic chemotherapy was prescribed after diagnosis; however, the patient died of respiratory complications during the induction phase of treatment. In this disease, it is necessary to establish the differential diagnosis with lymphoproliferative disorders, acute lymphoid and myeloid leukemias. The morphological analysis of neoplastic cells is, thus, an important aspect toward proper diagnostic guidance.

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Published

2019-06-28

Issue

Section

Case Report

How to Cite

1.
Flores-Angulo C, Chona Z, Sánchez MA, Salazar M, Hennig H. Blastic plasmacytoid dendritic cell neoplasm variant acute leukemia: case report. Rev Peru Med Exp Salud Publica [Internet]. 2019 Jun. 28 [cited 2024 Apr. 14];36(2):353-9. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/3779

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