Marcadores de resistencia plasmídica a quinolonas qnr en aislamientos clínicos de enterobacterias productoras de betalactamasas CTX-M en Lima, Perú

Lesdyth Jessica Toribio Arias; Carlos Raúl Sevilla Andrade; Edgar Gonzales-Escalante

doi:10.17843/rpmesp.2019.362.3960

Authors

Lesdyth Jessica Toribio Arias Escuela de Tecnología Médica, Universidad Nacional Mayor de San Marcos. Lima, Perú. Tecnólogo médico
Carlos Raúl Sevilla Andrade Escuela de Tecnología Médica, Universidad Nacional Mayor de San Marcos. Lima, Perú. Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales - CITBM, Universidad Nacional Mayor de San Marcos. Lima, Perú. magíster en Microbiología
Edgar Gonzales-Escalante Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales - CITBM, Universidad Nacional Mayor de San Marcos. Lima, Perú. Instituto Nacional de Salud del Niño. Lima, Perú. Tecnólogo médico, magíster en Microbiología

DOI:

https://doi.org/10.17843/rpmesp.2019.362.3960

Keywords:

Bacterial drug resistance, Quinolones, Beta-lactamases, Enterobacteriaceae

Abstract

Aimed at reporting markers of plasmid resistance to qnr quinolones in clinical isolates of CTX-M beta-lactamase-producing enterobacteria, a descriptive study was conducted with isolates from the strain repository of TO-06/09 project of the National Children´s Health Institute. 138 isolates were recovered. Antimicrobial susceptibility was determined by the diffusion disk method, and gene identification by polymerase chain reaction. Of the 138 isolates, 67 (48.5%) were genotypically positive for qnr proteins; of these, 38 (56.7%) had qnrB determinants and 48 (71.6%) had qnrS determinants. No isolate presented qnrA determinants. qnr determinants were detected in isolates containing CTX-M beta-lactamases in a non-exposed population.