Genetic polymorphism of apolipoprotein E in a peruvian population
DOI:
https://doi.org/10.17843/rpmesp.2011.284.420Keywords:
Alleles, Apolipoproteins E, Gene frequencyAbstract
Objectives. To determine the allelic and genotypic frequencies of the APOE gene in a sample of a population group in Peru. Materials and methods. Cross-sectional analytic study in 189 apparently healthy volunteers, workers of the Instituto Nacional de Ciencias Neurológicas in Lima, Perú, divided into 5 groups by birth department and two generations ancestry. Genomic DNA was amplified using PCR-RFLP. The resulting fragments were detected by 12 % polyacrylamide gel electrophoresis. Results. The Ɛ3 allele is the most frequent in all the groups (93.9 %), with low Ɛ4 (5 %) and Ɛ2 (1.1 %) allele frequencies. The analysis of heterozygosity (H) for each group displays intermediate diversity between 10 and 20%. Population genetic diversity (Ht) and diversity within populations (Hs) are 14.43 % and 14.31% respectively, suggesting genetic proximity between the studied groups for the ApoE polymorphism. Conclusions. Allele frequencies of the ApoE gene found show that allele Ɛ3 has one of the highest frequencies and Ɛ4 allele one of the lowest compared to other population groups in the world, with possible implications in the risk of neurological, cardiovascular and other diseases in our country.Downloads
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Published
2014-01-29
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Research Articles
How to Cite
1.
Marca V, Acosta O, Cornejo-Olivas M, Ortega O, Huerta D, Mazzetti P. Genetic polymorphism of apolipoprotein E in a peruvian population. Rev Peru Med Exp Salud Publica [Internet]. 2014 Jan. 29 [cited 2024 Nov. 13];28(4). Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/420