Molecular mechanisms of antibiotic resistance in Escherichia coli - associated diarrhea

Authors

  • Susan Mosquito Instituto de Medicina Tropical Alexander von Humbold, Universidad Peruana Cayetano Heredia. Lima, Perú. Facultad de Ciencias y Filosofía Alberto Cazorla Talleri, Universidad Peruana Cayetano Heredia. Lima, Perú. Bióloga, MSc. en Microbiología.
  • Joaquim Ruiz Centre de Recerca en Salut Internacional de Barcelona, Hospital Clinic, Universitat de Barcelona. Barcelona, España. Institut d’investigacions Biomèdiques August Pi i Sunyer. Barcelona, España. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública. Barcelona, España. Biólogo, PhD en Biología.
  • José Luis Bauer Facultad de Ciencias y Filosofía Alberto Cazorla Talleri, Universidad Peruana Cayetano Heredia. Lima, Perú. Microbiólogo, PhD en Ciencias con mención en Microbiología.
  • Theresa J. Ochoa Instituto de Medicina Tropical Alexander von Humbold, Universidad Peruana Cayetano Heredia. Lima, Perú. School of Public Health, University of Texas. Texas, EE.UU. Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. Médico, Pediatra Infectólogo.

DOI:

https://doi.org/10.17843/rpmesp.2011.284.430

Keywords:

Drug resistance, bacterial, Anti-bacterial agents, Escherichia coli

Abstract

Antibiotic resistance is an emerging problem worldwide present in many bacteria, specially in Escherichia coli, which has high percentages of resistance to ampicilline, thrimethoprim-sulfamethoxazole, tetracycline, chloramphenicol and nalidixic acid, which implies important complications in antibiotic treatment when required. The increasing antibiotic resistance is due to the acquisition of different molecular mechanisms of resistance through point chromosomal mutations and /or horizontal transfer of genetic material between related or different species facilitated by some genetic elements such as integrons. This review discusses the effects of the most common molecular mechanisms of antibiotic resistance in E. coli: enzymatic inactivation, changes in the target site and permeability disturbances. Getting to know the mechanisms of resistance which are involved, as the World Health Organization recommends, will allow us to improve the surveillance of the antibiotic resistance, the control policies and the antibiotic utilization at a national level.

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Published

2014-01-29

How to Cite

1.
Mosquito S, Ruiz J, Bauer JL, Ochoa TJ. Molecular mechanisms of antibiotic resistance in Escherichia coli - associated diarrhea. Rev Peru Med Exp Salud Publica [Internet]. 2014 Jan. 29 [cited 2024 Jun. 23];28(4). Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/430

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