Specificity of the intradermal montenegro test in patients infected by trypanosoma cruzi from different regions of Peru

Authors

  • Gloria Minaya-Gómez Centro Nacional de Salud Pública, Instituto Nacional de Salud. Lima, Perú. Bióloga, magíster en medicina tropical y salud internacional.
  • Silver Vargas-Apaza Centro Nacional de Salud Pública, Instituto Nacional de Salud. Lima, Perú. Biólogo, magíster en biotecnología.
  • Yolanda Monteza-Zuloeta Dirección Regional de Salud de San Martin. San Martín, Perú. Biólogo
  • Enrique Purisaca-Morante Dirección Regional de Salud de Amazonas. Amazonas, Perú. Biólogo.
  • Freddy Delgado-Diaz Dirección Regional de Salud de Arequipa. Arequipa, Perú. Médico cirujano.

DOI:

https://doi.org/10.17843/rpmesp.2014.312.46

Keywords:

Chagas disease, Leishmaniosis, Diagnosis, Hypersensitivity, delayed

Abstract

In order to assess the specificity of the leishmanin skin test in Chagas disease patients without clinical history of leishmaniasis, present or former. A sample of 102 persons infected with Trypanosoma cruzi (14 acute cases with parasitological diagnosis and 88 chronic cases) through the demonstration of IgG antibodies by ELISA and indirect immunofluorescence (IIF) were evaluated with leishmanin soluble antigen which contained Leishmania (Viannia) peruviana concentration of 25-30 ug/mL. Only five people showed cutaneous hypersensitivity reaction to the application of the antigen between hours 48 and 72. The Leishmanin skin test evaluated was negative in 97 people infected with T. cruzi, thus specificity of 95.1% was achieved. In conclusion, the intradermal Montenegro test is a simple and effective diagnostic tool that also could be used to discriminate infections by Leishmania or T. cruzi, in Peruvian geographic areas where both parasites are present.

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Published

2014-07-02

Issue

Section

Research Articles

How to Cite

1.
Minaya-Gómez G, Vargas-Apaza S, Monteza-Zuloeta Y, Purisaca-Morante E, Delgado-Diaz F. Specificity of the intradermal montenegro test in patients infected by trypanosoma cruzi from different regions of Peru. Rev Peru Med Exp Salud Publica [Internet]. 2014 Jul. 2 [cited 2024 Jun. 19];31(2). Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/46

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