Tiroiditis autoinmune inducida por interferón en pacientes con infección por virus de la hepatitis C

José L. Pinto; Miguel E. Pinto

doi:10.17843/rpmesp.2011.282.507

Authors

José L. Pinto Servicio de Gastroenterología, Hospital Nacional Cayetano Heredia, Lima, Perú. Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Perú. Médico gastroenterólogo.
Miguel E. Pinto Servicio de Endocrinología, Hospital Nacional Cayetano Heredia, Lima, Perú. Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Perú. Médico endocrinólogo.

DOI:

https://doi.org/10.17843/rpmesp.2011.282.507

Keywords:

Interferons, Hepatitis C, Thyroiditis, Graves Disease, Hyperthyroidism

Abstract

A 43 year old man presented with asymptomatic elevation of alanine aminotransferase (ALT) and no relevant past history. The patient denied being a chronic alcohol drinker. Work-up revealed an active hepatitis C, and liver biopsy showed active inflammation. Treatment was started with interferon-alfa and ribavirin. During the 48 weeks of treatment, the patient developed positive thyroid antibodies with varying level of thyrotropin (TSH) and thyroid hormones. At follow-up after treatment, the patient continued with hyperthyroidism due to Graves’ disease. Autoimmune thyroiditis is a common complication of using interferon in patients with hepatitis C. In some cases, it is presented as hyperthyroidism because of Graves’ disease. Thyroid function and thyroid antibodies should be evaluated before and during treatment with interferon.