Colistin resistance in multidrug-resistant Klebsiella pneumoniae strains at a perinatal maternal institute in Lima, Peru, 2015-2018

Authors

DOI:

https://doi.org/10.17843/rpmesp.2020.374.5422

Keywords:

Klebsiella pneumoniae, Antimicrobial Drug Resistance, Colistin, beta-Lactams

Abstract

The objective of this study was to evaluate the presence of colistin- and carbapenemic-resistant genes in multidrug-resistant Klebsiella pneumoniae strains isolated at the Instituto Materno Perinatal de Lima (2015-2018). Susceptibility levels were analyzed by disk diffusion and microdilution. The presence of colistin- and carbapenemic-resistant genes was determined by polymerase chain reaction (PCR) and was related to clonality. A total of 36 K. pneumoniae strains were analyzed, 5 (13.8%) were resistant to colistin and belonged to different clonal groups. Only 2 strains were found with carbapenemases (blaKPC and blaNDM), and no colistin plasmid genes were detected. High resistance levels to the other tested antimicrobials were observed, except for amikacin (13.9%). The results highlight the presence of colistinresistant strains (33.3% in 2018), a worrying situation as they are part of the latest treatment alternatives for infections caused by multiresistant pathogens.

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Author Biographies

  • Andrea Naomi-Matsuoka, Facultad de Medicina Humana, Universidad Científica del Sur, Lima, Perú. Médica cirujana
    Licenciada en Medicina por la Universidad Científica del Sur
  • Marina Vargas, Facultad de Medicina Humana, Universidad Científica del Sur, Lima, Perú. Médica cirujana
    Licenciada en Medicina por la Universidad Científica del Sur
  • Barbara Ymaña, Facultad de Medicina Humana, Universidad Científica del Sur, Lima, Perú. bióloga
    Licenciada de Biología por la Universidad Ricardo Palma
  • Maria J. Pons, Facultad de Medicina Humana, Universidad Científica del Sur, Lima, Perú. bióloga; doctora en Biología
    Biologa, PhD, Investigadora en la Universidad Cientifica del Sur.

Published

2020-10-06

Issue

Section

Brief Report

How to Cite

1.
Naomi-Matsuoka A, Vargas M, Ymaña B, Soza G, Pons MJ. Colistin resistance in multidrug-resistant Klebsiella pneumoniae strains at a perinatal maternal institute in Lima, Peru, 2015-2018. Rev Peru Med Exp Salud Publica [Internet]. 2020 Oct. 6 [cited 2024 May 23];37(4):716-20. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/5422

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