Colistin resistance in multidrug-resistant Klebsiella pneumoniae strains at a perinatal maternal institute in Lima, Peru, 2015-2018
DOI:
https://doi.org/10.17843/rpmesp.2020.374.5422Keywords:
Klebsiella pneumoniae, Antimicrobial Drug Resistance, Colistin, beta-LactamsAbstract
The objective of this study was to evaluate the presence of colistin- and carbapenemic-resistant genes in multidrug-resistant Klebsiella pneumoniae strains isolated at the Instituto Materno Perinatal de Lima (2015-2018). Susceptibility levels were analyzed by disk diffusion and microdilution. The presence of colistin- and carbapenemic-resistant genes was determined by polymerase chain reaction (PCR) and was related to clonality. A total of 36 K. pneumoniae strains were analyzed, 5 (13.8%) were resistant to colistin and belonged to different clonal groups. Only 2 strains were found with carbapenemases (blaKPC and blaNDM), and no colistin plasmid genes were detected. High resistance levels to the other tested antimicrobials were observed, except for amikacin (13.9%). The results highlight the presence of colistinresistant strains (33.3% in 2018), a worrying situation as they are part of the latest treatment alternatives for infections caused by multiresistant pathogens.Downloads
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Published
2020-10-06
Issue
Section
Brief Report
How to Cite
1.
Naomi-Matsuoka A, Vargas M, Ymaña B, Soza G, Pons MJ. Colistin resistance in multidrug-resistant Klebsiella pneumoniae strains at a perinatal maternal institute in Lima, Peru, 2015-2018. Rev Peru Med Exp Salud Publica [Internet]. 2020 Oct. 6 [cited 2024 Dec. 13];37(4):716-20. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/5422