Efficacy of two locally produced oxfendazole formulations for the treatment of cysticercosis in naturally infected pigs

Authors

  • Gianfranco Arroyo Centro de Salud Global y Departamento de Microbiología, Universidad Peruana Cayetano Heredia, Lima, Perú.Médico veterinario; magíster en Salud Animal https://orcid.org/0000-0001-8743-5012
  • Javier A. Bustos Centro de Salud Global y Departamento de Microbiología, Universidad Peruana Cayetano Heredia, Lima, Perú.médico cirujano, doctor en Salud Pública https://orcid.org/0000-0002-5797-3052
  • Juan F. Calcina Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Perú. Médico veterinario https://orcid.org/0000-0003-4464-3107
  • Linda Gallegos Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Perú. Médico veterinario https://orcid.org/0000-0001-9608-4875
  • Ana Vargas-Calla Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Perú.Médico veterinario; magíster en Salud Animal https://orcid.org/0000-0002-8993-3223
  • Luis A. Gomez-Puerta Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Perú.Médico veterinario; magíster en Salud Animal https://orcid.org/0000-0002-7909-979X
  • Teresa Lopez Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Perú.Médico veterinario; doctor en MedicinaVeterinaria https://orcid.org/0000-0002-8389-4139
  • Robert H. Gilman Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, Estados Unidos.médico cirujano, doctor en Salud Pública https://orcid.org/0000-0002-9037-0712
  • Héctor H. Garcia Centro de Salud Global y Departamento de Microbiología, Universidad Peruana Cayetano Heredia, Lima, Perú.Unidad de Cisticercosis, Instituto Nacional de Ciencias Neurológicas, Lima, Perú.médico cirujano, doctor en Salud Pública https://orcid.org/0000-0002-4633-6269
  • Armando E. Gonzalez Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Perú.Médico veterinario; doctor en MedicinaVeterinaria. https://orcid.org/0000-0003-1909-1873
  • Grupo de Trabajo en Cisticercosis en Perú

DOI:

https://doi.org/10.17843/rpmesp.2021.382.6539

Keywords:

Cysticercosis, Dosage, Cysts, Porcine, Taenia solium, Peru

Abstract

The efficacy of two locally produced oxfendazole (OFZ) formulations against cysticercosis at 22,5% and 10%, versus a commercial formulation (Synanthic 9,06%) was evaluated in twenty-two naturally infected pigs that received a single oral dose of 30 mg/kg. Pigs were sacrificed at eight weeks post-treatment to evaluate the cysts found in their carcasses, and to determine the cysticidal efficacy, which was defined as the proportion of degenerated cysts over total cysts. Only degenerated cysts were found in muscle, heart, and tongue of pigs treated with OFZ in all groups, which shows an efficacy of 100%. Viable and degenerated cysts were found in brains, being the efficacy lower in all groups (65% [commercial OFZ], 47% [local OFZ 22.5%] and 31% [local OFZ 10%], p = 0.355). Locally produced OFZ formulations were similarly effective to the commercial formulation and may provide a practical alternative for the treatment of porcine cysticercosis.

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Published

2021-07-01

Issue

Section

Brief Report

How to Cite

1.
Arroyo G, Bustos JA, Calcina JF, Gallegos L, Vargas-Calla A, Gomez-Puerta LA, et al. Efficacy of two locally produced oxfendazole formulations for the treatment of cysticercosis in naturally infected pigs. Rev Peru Med Exp Salud Publica [Internet]. 2021 Jul. 1 [cited 2024 Jun. 21];38(2):296-301. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/6539

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