Parametrial involvement in cervical cancer IB1 patients treated with radical hysterectomy in Peru

Authors

  • Carlos Urrutia Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. Cirujano oncólogo
  • Carlos Santos Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. Cirujano oncólogo
  • Albert Zevallos Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. Cirujano oncólogo
  • Aldo López Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. Cirujano oncólogo
  • Absalón Montoya Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. Cirujano oncólogo
  • Marco Sánchez Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. Cirujano oncólogo
  • Henry Valdivia Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. cirujano oncólogo, magíster en Salud Publica
  • Carlos Velarde Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. Cirujano oncólogo
  • Raúl Mantilla Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. bachiller en Bioestadística
  • Esperanza Milla Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. médico patólogo
  • Carlos Castañeda Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. oncólogo clínico, magíster en Genética y Biología Celular, magíster en Oncología Avanzada
  • Mayer Zaharia Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. médico radioncólogo, magíster en Radioncología, doctor en Medicina
  • Manuel Álvarez Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. cirujano oncólogo, magíster en Medicina

DOI:

https://doi.org/10.17843/rpmesp.2014.313.77

Keywords:

Uterine cervical neoplasms, Hysterectomy, Lymph node excision

Abstract

Objectives. To assess the frequency and factors associated with parametrial involvement (PI) in patients with cervical cancer IB1 who underwent radical hysterectomy (RH) at the National Institute of Neoplastic Diseases in Peru. Materials and methods. Cross-sectional study of 214 patients with cervical cancer IB1 undergoing RH with pelvic lymphadenectomy between 2007 and 2012. The population was compared with and without clinicopathological variables associated with PI such as age, tumor size, depth of infiltration, histological grade and pelvic lymph node involvement. Results. Ten patients (4.6%) had PI. Multivariate analysis showed that the depth of invasion (OR 8.37, 95% CI 1.24- 56.41, p=0.029) and pelvic node involvement (OR 18.03; 95% CI 3.30-98.44, p=0.001) were all independent predictors of PI. The presence of tumor size ≤ 2 cm, invasion ≤ 10 mm, absence of lymphovascular permeation and absence of nodal involvement identified 97 patients at low risk of PI, none of whom had PI pathology. Conclusions. We confirmed the low frequency of PI in the cervical cancer IB1 subgroup and its association with the depth of invasion and lymph node involvement suggested in previous studies. This information will allow the identification of a subgroup of patients at low risk of PI for less radical surgery in our institution.

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Published

2014-09-25

Issue

Section

Research Articles

How to Cite

1.
Urrutia C, Santos C, Zevallos A, López A, Montoya A, Sánchez M, et al. Parametrial involvement in cervical cancer IB1 patients treated with radical hysterectomy in Peru. Rev Peru Med Exp Salud Publica [Internet]. 2014 Sep. 25 [cited 2024 Jun. 13];31(3). Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/77

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