Allergic rhinitis associated with the degree of pulmonary involvement due to COVID-19 in patients from a peruvian general hospital

Authors

DOI:

https://doi.org/10.17843/rpmesp.2023.401.12491

Keywords:

Rhinitis, Allergic, Coronavirus Infections, Lung Injury, Patient Acuity

Abstract

Objectives. To evaluate the association between allergic rhinitis and the degree of pulmonary involvement in patients with COVID-19 and to determine the frequencies of the main variables. Materials and methods. An observational, cross-sectional and analytical study was carried out by reviewing the medical records of patients diagnosed with COVID-19 from the Cayetano Heredia National Hospital between 2020 and 2021. We obtained information regarding the history of allergic rhinitis; pulmonary involvement was assessed by non-contrast tomography results using the chest computed tomography (CT) score. Data regarding sociodemographic and clinical variables was also obtained. Both crude (PR) and adjusted (aPR) prevalence ratios with their respective 95% confidence intervals (CI) were estimated. We also used a generalized linear Poisson family model with log link function and robust variances. Results. We evaluated 434 patients, who were mostly male, older than 60 years and had no relevant
medical history. Of these, 56.2% had a history of allergic rhinitis and 43.1% had moderate to severe pulmonary
involvement. The adjusted regression model showed that the history of allergic rhinitis reduced the severity of COVID-19 according to the pulmonary involvement assessed by the CT score (aPR: 0.70; 95%CI: 0.56-0.88; p=0.002). Conclusions. The history of allergic rhinitis resulted in a 30.0% decrease in COVID-19 severity according to the CT score in hospitalized patients.

Downloads

Download data is not yet available.

References

Johns Hopkins CSSE [Internet]. 2020. Coronavirus COVID-19 (2019-nCoV). Coronavirus COVID-19 Global Cases by Johns Hopkins

CSSE [Internet]. Johns Hopkins; 2020 [citado el 21 de marzo de 2023]. Disponible en: https://www.arcgis.com/apps/dashboards/bda7594740fd40299423467b48e9ecf6.

Izcovich A, Ragusa MA, Tortosa F, Lavena Marzio MA, Agnoletti C, Bengolea A, et al. Prognostic factors for severity and mortality in

patients infected with COVID-19: A systematic review. PLoS One. 2020;15(11):e0241955. doi: 10.1371/journal.pone.0241955.

Huang I, Lim MA, Pranata R. Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia - A systematic review, meta-analysis, and meta-regression. Diabetes Metab Syndr. 2020;14(4):395-403. doi: 10.1016/j.dsx.2020.04.018.

Zheng Z, Peng F, Xu B, Zhao J, Liu H, Peng J, et al. Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis. J Infect. 2020;81(2):e16-e25. doi: 10.1016/j.jinf.2020.04.021.

Jordan RE, Adab P, Cheng KK. Covid-19: risk factors for severe disease and death. BMJ. 2020;368:m1198. doi: 10.1136/bmj.m1198.

Yang JM, Koh HY, Moon SY, Yoo IK, Ha EK, You S, et al. Allergic disorders and susceptibility to and severity of COVID-19: A nationwide cohort study. J Allergy Clin Immunol. 2020;146(4):790–8. doi: 10.1016/j.jaci.2020.08.008.

Xu C, Zhao H, Song Y, Zhou J, Wu T, Qiu J, et al. The Association between Allergic Rhinitis and COVID-19: A Systematic Review and Meta-Analysis. Int J Clin Pract. 2022;2022:6510332. doi: 10.1155/2022/6510332.

Amin K, Issa SM, Ali KM, Aziz MI, Hama Amieen HM, Bystrom J, et al. Evidence for eosinophil and IL-17 mediated inflammation in allergic rhinitis. Clin Mol Allergy. 2020;18:6. doi: 10.1186/s12948-020-00117-6.

Soy M, Keser G, Atagündüz P, Tabak F, Atagündüz I, Kayhan S. Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment. Clin Rheumatol. 2020;39(7):2085-2094. doi: 10.1007/s10067-020-05190-5.

Meng Y, Wang C, Zhang L. Advances and novel developments in allergic rhinitis. Allergy. 2020;75(12):3069-3076. doi: 10.1111/all.14586.

Baumann LM, Romero KM, Robinson CL, Hansel NN, Gilman RH, Hamilton RG, et al. Prevalence and risk factors for allergic rhinitis in two resource-limited settings in Peru with disparate degrees of urbanization. Clin Exp Allergy. 2015;45(1):192-9. doi: 10.1111/cea.12379.

Neffen H, Mello JF Jr, Sole D, Naspitz CK, Dodero AE, Garza HL, Guerra EN, et al. Nasal allergies in the Latin American population: results from the Allergies in Latin America survey. Allergy Asthma Proc. 2010;31Suppl1: S9-27. doi: 10.2500/aap.2010.31.3347.

Rosario Filho NA, Satoris RA, Scala WR. Allergic rhinitis aggravated by air pollutants in Latin America: A systematic review. World Allergy Organ J. 2021;14(8):100574. doi: 10.1016/j.waojou.2021.100574.

Francone M, Iafrate F, Masci GM, Coco S, Cilia F, Manganaro L, et al. Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis. Eur Radiol. 2020;30(12):6808-6817. doi: 10.1007/s00330-020-07033-y.

Saeed GA, Gaba W, Shah A, Al Helali AA, Raidullah E, Al Ali AB, et al. Correlation between Chest CT Severity Scores and the Clinical Parameters of Adult Patients with COVID-19 Pneumonia. Radiol Res Pract. 2021;2021:6697677. doi: 10.1155/2021/6697677.

Pan F, Ye T, Sun P, Gui S, Liang B, Li L, et al. Time Course of Lung Changes at Chest CT during Recovery from Coronavirus Disease

(COVID-19). Radiology. 2020;295(3):715-721. doi: 10.1148/radiol.2020200370.

Matsushita K, Ding N, Kou M, Hu X, Chen M, Gao Y, et al. The Relationship of COVID-19 Severity with Cardiovascular Disease and Its

Traditional Risk Factors: A Systematic Review and Meta-Analysis. Glob Heart. 2020;15(1):64. doi: 10.5334/gh.814.

Brunetto O. Corticoterapia Prolongada. Rev Ped Eliz. 2017;8(1y2):57–60.

Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934-943. doi: 10.1001/jamainternmed.2020.0994.

Jackson DJ, Busse WW, Bacharier LB, Kattan M, O’Connor GT, Wood RA, et al. Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2. J Allergy Clin Immunol. 2020;146(1):203-206.e3. doi: 10.1016/j.jaci.2020.04.009.

Gani F, Cottini M, Landi M, Berti A, Comberiati P, Peroni D, et al. Allergic rhinitis and COVID-19: friends or foes? Eur Ann Allergy Clin Immunol. 2022;54(2):53-59. doi: 10.23822/EurAnnACI.1764-1489.234.

Kimura H, Francisco D, Conway M, Martinez FD, Vercelli D, Polverino F, et al. Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells. J Allergy Clin Immunol. 2020;146(1):80-88.e8. doi: 10.1016/j.jaci.2020.05.004.

Ge S, Wang X, Hou Y, Lv Y, Wang C, He H. Repositioning of histamine H1 receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2. Eur J Pharmacol. 2021;896:173897. doi: 10.1016/j.ejphar.2021.173897.

Vila-Córcoles A, Ochoa-Gondar O, Satué-Gracia EM, Torrente-Fraga C, Gomez-Bertomeu F, Vila-Rovira A, et al. Influence of prior comorbidities and chronic medications use on the risk of COVID-19 in adults: a population-based cohort study in Tarragona, Spain. BMJ Open. 2020;10(12):e041577. doi: 10.1136/bmjopen-2020-041577.

Published

2023-03-30

Issue

Section

Original Article

How to Cite

1.
García-Gallo B, Gonzales-Caldas G, Urrunaga-Pastor D, Herrera-Añazco P. Allergic rhinitis associated with the degree of pulmonary involvement due to COVID-19 in patients from a peruvian general hospital. Rev Peru Med Exp Salud Publica [Internet]. 2023 Mar. 30 [cited 2024 Nov. 2];40(1):51-8. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/12491

Most read articles by the same author(s)

1 2 > >>