Identificación de enterobacterias multirresistentes a antibióticos en muestras de heces de lactantes residentes en Talara, Piura, Perú

Arturo Octavio Gonzales-Rodríguez; Javier Ignacio Castillo Horna; Edgar Gonzales Escalante

doi:10.17843/rpmesp.2022.394.11870

Authors

Arturo Octavio Gonzales-Rodríguez Facultad de Medicina Humana, Universidad de Piura, Lima, Perú https://orcid.org/0000-0002-6377-1596
Javier Ignacio Castillo Horna Facultad de Medicina Humana, Universidad de Piura, Lima, Perú https://orcid.org/0000-0001-7987-0233
Edgar Gonzales Escalante Facultad de Medicina Humana, Universidad de Piura, Lima, Perú; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Instituto de Investigaciones en Bacteriología y Virología Molecular (IBaViM), Argentina https://orcid.org/0000-0002-3411-9021

DOI:

https://doi.org/10.17843/rpmesp.2022.394.11870

Keywords:

Newborn, Escherichia coli, Drug Resistance, beta-Lactamases, Quinolones, Peru, Coliforms

Abstract

Fecal colonization in infants by antimicrobial-resistant bacteria is a potential risk for future antibiotic therapy. We determine the frequency and sociodemographic characteristics of infants who are fecal carriers of Enterobacteriaceae resistant to ciprofloxacin (PFRC) and their associated resistance genes. We obtainfecal samples from 41 nursing children residing in the district of Talara - Piura, Peru, were analyzed in 2019. The presence of 3 quinolone resistance genes was evaluated: aac(6’)-Ib-cr, qnrB and oqxA and 2 of beta-lactamases: blaCTX-M,blaPER-2. 68% of infants were PFRC, Escherichia coli (83.3%) was the most frequent. Genotypic analysis detected: oqxA (41.1%), qnrB (26.7%) and aac(6’)-Ib-cr (20%) and the blaCTX-M gene in 93.3% of the isolates with beta-lactamases. The high frequency of PFRC alert us to the potential risk in the loss of usefulness of this antibiotic family in the study area.

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