Hematological profiles of malaria-infected patients in an endemic area of Peru

Authors

  • Viviana Pinedo-Cancino Laboratorio de Investigación de Productos Naturales Antiparasitarios de la Amazonía, Centro de Investigación de Recursos Naturales, Universidad Nacional de la Amazonía Peruana, Iquitos, Perú; Facultad de Medicina Humana, Universidad Nacional de la Amazonía Peruana, Iquitos, Perú https://orcid.org/0000-0003-0035-563X
  • Katty M. Arista Laboratorio de Investigación de Productos Naturales Antiparasitarios de la Amazonía, Centro de Investigación de Recursos Naturales, Universidad Nacional de la Amazonía Peruana, Iquitos, Perú https://orcid.org/0000-0002-1890-9314
  • Andree Valle-Campos Departamento de Ciencias Biológicas. Universidad Nacional Mayor de San Marcos, Lima, Perú. https://orcid.org/0000-0002-7779-481X
  • Rafael Saavedra-Langer Departamento de Bioquímica e Inmunología, Instituto de Ciencias Biológicas, Universidad Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0000-0001-6849-3794
  • Cristian Roca Departamento de Microbiología e Inmunología, Universidad de Carolina del Norte, Chapel Hill, Estados Unidos https://orcid.org/0000-0003-2522-0360
  • José-Manuel Ramos-Rincón Departamento de Medicina Interna, Hospital General Universitario de Alicante-ISABIAL, Alicante, España; Departamento de Medicina Clínica, Universidad Miguel Hernández de Elche, Alicante, España https://orcid.org/0000-0002-6501-9867
  • Maritza Calderón Laboratorio de Investigación en Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Perú https://orcid.org/0000-0001-6582-7306
  • Oralee H. Branch Lark Health, Estudios clínicos, Mountain View, California, Estados Unidos https://orcid.org/0000-0002-6720-6906

DOI:

https://doi.org/10.17843/rpmesp.2022.393.11908

Keywords:

Plasmodium, Blood Cell Count, Platelets, Tropical Disease, Peruvian Amazon, Parasites

Abstract

Objectives. To evaluate the variation of hematological profiles of patients infected with uncomplicated Plasmodium vivax (Pv) and P. falciparum (Pf) malaria before, during and after treatment in a population of the Loreto region. Materials and methods. This study was conducted between 2010 and 2012, in Zungarococha (Iquitos).
The 425 participants had three visits (visit 1-day 0-before treatment, visit 2-day 7-during treatment, visit 3-day 28-after treatment), complete blood count, microscopic and molecular diagnosis (PCR). Results. At the first visit, 93 (21.9%) participants were found positive for Pv and 34 (8.0%) for Pf. All positives showed a reduction in hematocrit, white blood cell count (WBC), ablated and segmented neutrophils, eosinophils and platelets
(p<0.001) compared to the negative group. A higher percentage of ablated neutrophils was found in Pf and segmented neutrophils in Pv compared to the negative group. Variations in hematological profiles were observed after treatment for both species; ablated neutrophils decreased, platelets increased, eosinophils increased at day 7 and declined at day 28, hematocrit and segmented neutrophils decreased at day 7 and normalized at day 28. Interspecies differences over time showed a bigger daily decrease in ablated neutrophils in Pv-infected when compared to Pf. Conclusions. The hematological profile in uncomplicated malaria-positive patients varies over time during and after treatment. These are indicators of disease progression and help in the therapeutic surveillance
of Plasmodium-infected patients.

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Published

2022-09-30

Issue

Section

Original Article

How to Cite

1.
Pinedo-Cancino V, Arista KM, Valle-Campos A, Saavedra-Langer R, Roca C, Ramos-Rincón J-M, et al. Hematological profiles of malaria-infected patients in an endemic area of Peru. Rev Peru Med Exp Salud Publica [Internet]. 2022 Sep. 30 [cited 2024 Apr. 24];39(3):336-44. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/11908

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