Monkeypox in a patient with HIV: case report

Authors

DOI:

https://doi.org/10.17843/rpmesp.2023.402.12344

Keywords:

Viruela Símica, VIH, Sífilis, Gonorrea, Virus de la Viruela del Simio, Proctitis, Bolivia

Abstract

Monkeypox (Mpox) is a zoonotic disease, endemic in some areas of Africa. But since May 2022, multiple cases of Mpox have been reported in non-endemic countries. We present the case of a patient with a history of HIV, as well as rash in several areas of the body, mostly in the gluteal region, associated with cervical lymphadenopathy and infectious proctitis. Diagnosis was confirmed by real-time polymerase chain reaction (RT-PCR) of skin lesion samples. Treponema pallidum and Neisseria gonorrhoeae infection was confirmed by serology and rectal discharge culture, respectively. The patient received antibiotics specific for gonorrhea
and syphilis and his condition improved due to symptomatic and immunomodulatory therapy.

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References

Sklenovská N, Van Ranst M. Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans. Front Public Health. 2018; 6:241. doi: 10.3389/fpubh.2018.00241.

Al-Tawfiq JA, Barry M, Memish ZA. International outbreaks of Monkeypox virus infection with no established travel: A public health concern with significant knowledge gap. Travel Med Infect Dis. 2022; 49:102364. doi: 10.1016/j.tmaid.2022.102364.

Gong Q, Wang C, Chuai X, Chiu S. Monkeypox virus: a re-emergent threat to humans. Virol Sin. 2022;37(4):477-482. doi:10.1016/j.virs.2022.07.006.

Nuzzo JB, Borio LL, Gostin LO. The WHO Declaration of Monkeypox as a Global Public Health Emergency. JAMA. 2022; 328(7):615-617. doi: 10.1001/jama.2022.12513.

Centers for Disease Control and Prevention. [Internet]. 2023. Mpox Outbreak Global Map 2022. [citado el 18 de marzo de 2023]. Disponible en: https://www.cdc.gov/poxvirus/mpox/response/2022/world-map.html.

World Health Organization. [Internet]. 2023. Multi-country outbreak of mpox, External situation report #18 - 16 March 2023 [citado el 18 de marzo de 2023]. Disponible en: https://www.who.int/publications/m/item/multi-country-outbreak-of-mpox--external-situation-report--18---16-march-2023.

Franco AO, Moreno Samper D, Chaparro Mérida NA. Viruela del Simio. Rev Chil Infectol. 2022; 39(4):457-66.

Rimoin AW, Kisalu N, Kebela-Ilunga B, Mukaba T, Wright LL, Formenty P, et al. Endemic human monkeypox, Democratic Republic of Congo, 2001- 2004. Emerg Infect Dis. 2007;13(6):934-7. doi: 10.3201/eid1306.061540.

Hraib M, Jouni S, Albitar MM, Alaidi S, Alshehabi Z. The outbreak of monkeypox 2022: An overview. Ann Med Surg (Lond). 2022; 24;79:104069. doi: 10.1016/j.amsu.2022.104069.

Thornhill JP, Barkati S, Walmsley S, Rockstroh J, Antinori A, Harrison LB, et al. Monkeypox Virus Infection in Humans across 16 Countries - April-June 2022. N Engl J Med. 2022; 25;387(8):679-691. doi: 10.1056/NEJMoa2207323.

Lum FM, Torres-Ruesta A, Tay MZ, Lin RTP, Lye DC, Rénia L, et al. Monkeypox: disease epidemiology, host immunity and clinical interventions. Nat Rev Immunol. 2022; 22(10):597-613. doi: 10.1038/s41577-022-00775-4.

Huhn GD, Bauer AM, Yorita K, Graham MB, Sejvar J, Likos A, et al. Clinical characteristics of human monkeypox, and risk factors for severe disease. Clin Infect Dis. 2005; 41(12):1742-51. doi: 10.1086/498115.

Patel A, Bilinska J, Tam JCH, Da Silva Fontoura D, Mason CY, Daunt A, et al. Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series. BMJ. 2022; 28;378:e072410. doi: 10.1136/bmj-2022-072410.

Workowski KA, Bachmann LH, Chan PA, Johnston CM, Muzny CA, Park I, et al. Sexually Transmitted Infections Treatment Guidelines. MMWR Recomm Rep. 2021; 70(4):1-187. doi: 10.15585/mmwr.rr7004a1.

Sigle GW, Kim R. Sexually transmitted proctitis. Clin Colon Rectal Surg. 2015; 28(2):70-8. 10.1055/s-0035-1547334.

Bejarano Rengifo J, Cañadas Garrido R. Proctitis infecciosa transmitida sexualmente: reto diagnóstico y recomendaciones de tratamiento. Rev Gastroenterol Peru. 2020;40(4):336-41. doi: 10.47892/rgp.2020.404.1172.

Mailhe M, Beaumont AL, Thy M, Le Pluart D, Perrineau S, Houhou-Fidouh N, et al. Clinical characteristics of ambulatory and hospitalized patients with monkeypox virus infection: an observational cohort study. Clin Microbiol Infect. 2023;29(2):233-239. doi: 10.1016/j.cmi.2022.08.012.

Hammarlund E, Dasgupta A, Pinilla C, Norori P, Früh K, Slifka MK. Monkeypox virus evades antiviral CD4+ and CD8+ T cell responses by suppressing cognate T cell activation. Proc Natl Acad Sci U S A. 2008;105(38):14567-72. doi: 10.1073/pnas.0800589105.

Cruz Barrios M, Furones Mourelle J. Beneficio-riesgo del uso de factor de transferencia (Hebertrans®) en la práctica médica habitual. Horizonte Sanitario. 2019;18(2):235-42. doi: 10.19136/hs.a18n2.2918.

Messina MD, Wolf EL, Kanmaniraja D, Alpert PL, Ricci ZJ. Imaging features of anorectal proctitis in monkeypox infection. Clin Imaging. 2022; 92:109-111. doi: 10.1016/j.clinimag.2022.10.008.

Published

2023-05-10

Issue

Section

Case Report

How to Cite

1.
Franco Lacato AO, Chaparro Mérida NA, Moreno Samper D, Orellana Padilla DS, Vides Melendres D, Auza Santivañez JC. Monkeypox in a patient with HIV: case report. Rev Peru Med Exp Salud Publica [Internet]. 2023 May 10 [cited 2024 May 2];40(2):229-35. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/12344

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