SARS-CoV-2 infection in pregnancy: clinical characteristics and vertical  transmission in a reference hospital in Peru

Authors

DOI:

https://doi.org/10.17843/rpmesp.2024.412.13293

Keywords:

Infectious disease transmission vertical, COVID-19, Pregnancy, Newborn

Abstract

The study carried out in the Department of Gynecology and Obstetrics of the Edgardo Rebagliati Martins National Hospital (HNERM) aimed to analyze the vertical transmission of the SARS-CoV-2 virus in pregnant women with COVID-19. Twelve pregnant women who met the established inclusion criteria were included. Real-time PCR (RT-PCR) diagnostic testing for SARS-CoV-2 was performed during the admission of each pregnant patient, and placenta samples were collected for pathological evaluation. The results showed that vertical transmission of the virus was rare, with an overall low positivity rate in newborns. Although the study has limitations, such as the small number of cases and the lack of electron microscope analysis, it constitutes the first attempt in Peru to evaluate vertical transmission. It is concluded that more research is needed to better understand the relationship between COVID-19 infection and complications during pregnancy.

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References

World Health Organization. WHO COVID-19 dashboard. [Internet]. Ginebra: WHO; 2024. https://data.who.int/dashboards/covid19/cases.

Akhtar H, Patel C, Abuelgasim E, Harky A. COVID-19 (SARS-CoV-2) Infection in Pregnancy: A Systematic Review. Gynecol Obstet Invest. 2020;85(4): 295-306. doi: 10.1159/000509290.

Ministerio de Salud. Sala de Situación SE 08 - 2022. Perú: Centro Nacional de Epidemiología, Prevención y Control de Enfermedades – MINSA. 2022. https://www.dge.gob.pe/portal/docs/vigilancia/sala/2022/SE08/mmaterna.pdf.

Dávila-Aliaga C, Hinojoza-Pérez R, Espinola-Sánchez M, Torres-Marcos E, Guevara-Ríos E, Espinoza-Vivas Y, et al. Resultados

materno-perinatales en gestantes con COVID-19 en un hospital nivel III del Perú. Rev Peru Med Exp Salud Pública. 2021;38(1):58-63. doi: 10.17843/rpmesp.2021.381.6358.

Capobianco G, Saderi L, Aliberti S, Mondoni M, Piana A, Dessole F, et al. COVID-19 in pregnant women: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2020; 252:543-58. doi: 10.1016/j.ejogrb.2020.07.006.

Kotlyar AM, Grechukhina O, Chen A, Popkhadze S, Grimshaw A, Tal O, et al. Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis. Am J Obstet Gynecol. 2021; 224(1):35-53. e3. doi: 10.1016/j.ajog.2020.07.049.

Yan J, Guo J, Fan C, Juan J, Yu X, Li J, et al. Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am J Obst Gynecol. 2020; 223(1):111.e1-111.e14. doi: 10.1016/j.ajog.2020.04.014.

Della Gatta AN, Rizzo R, Pilu G, Simonazzi Coronavirus disease 2019 during pregnancy: a systematic review of reported cases. Am J Obst Gynecol. 2020; 223(1): 34-41. doi: 10.1016/j.ajog.2020.04.013.

Lamouroux A, Attie-Bitach T, Martinovic J, Leruez-Ville M, Ville Y. Evidence for and against vertical transmission for SARS-CoV-2 (COVID-19). Am J Obstet Gynecol. 2020; 223(1): 91.e1-91.e4. doi: 10.1016/j.ajog.2020.04.039.

Allotey J, Chatterjee S, Kew T, Gaetano A, Stallings E, Fernández-García S, et al. SARS-CoV-2 positivity in offspring and timing

of mother-to-child transmission: living systematic review and meta-analysis. BMJ. 2022; 376: e067696. doi: 10.1136/bmj-2021-067696.

Kirtsman M, Diambomba Y, Poutanen SM, Malinowski AK, Vlachodimitropoulou E, Parks WT, et al. Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection. CMAJ. 2020; 192(24): E647-E650. doi: 10.1503/cmaj.200821.

Khong TY, Mooney EE, Ariel I, Balmus NCM, Boyd Tk, Brundler MA, et al. Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement. Arch Pathol Lab Med. 2016;140(7):698-13. doi: 10.5858/arpa.2015-0225-CC.

Vivanti AJ, Vauloup-Fellous C, Prevot S, Zupan V, Suffee C, Do Cao J, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11(1):3572. doi: 10.1038/s41467-020-17436-6.

Algarroba AN, Hanna NH, Rekawek P, Vahanian SA, Khullar P, Palaia T, et al. Confirmatory evidence of the visualization of severe acute respiratory syndrome coronavirus 2 invading the human placenta using electron microscopy. Am J Obstet Gynecol. 2020;223(6):953-4. doi: 10.1016/j.ajog.2020.08.106.

Penfield CA, Brubaker SG, Limaye MA, Lighter J, Ratner Aj, Thomas KM, et al. Detection of SARS-COV-2 in placental and fetal membrane samples. Am J Obstet Ginecol MFM. 2020; 2(3):1-2. doi: 10.1016/j.ajogmf.2020.100133.

Pulinx B, Kieffer D, Michiels I, Petermans S, Strybol D, Delvaux S, et al. Vertical transmission of SARS-CoV-2 infection and preterm birth. Eur J Microbiol Infect Dis. 2020; 39(12):2441-5. doi: 10.1007/s10096-020-03964-y.

Dong L, Tian J, He S, Zhu C, Wang J, Liu C, et al. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. 2020;323(18):1846-48. doi: 10.1001/jama.2020.4621.

Shanes ED, Mithal LB, Otero S, Azad HA, Miller ES, Goldstein. Placental Pathology in COVID-19. Am J Clin Pathol. 2020;154(1): 23-32. doi: 10.1093/ajcp/aqaa089.

Juan J, Gil MM, Rong Z, Zhang Y, Yang H, Poon LC. Effect of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcome: systematic review. Ultrasound Obstet Gynecol. 2020; 56(1):15-27. doi: 10.1002/uog.22088.

Zamaniyan M, Ebadi A, Aghajanpoor S, Rahmani Z, Haghshenas M, Azizi S. Preterm delivery, maternal death, and vertical transmission in a pregnant woman with COVID-19 infection. Prenat Diagn. 2020;40(13):1759-61. doi: 10.1002/pd.5713.

Published

2024-06-21

Issue

Section

Brief Report

How to Cite

1.
Urbina-Alvarez CA, Sifuentes-Alvarez JC, Moreno-Bocanegra JF, Vasquez-Sandoval K, Huiza- Espinoza L, La Rosa-De los Rios M, et al. SARS-CoV-2 infection in pregnancy: clinical characteristics and vertical  transmission in a reference hospital in Peru. Rev Peru Med Exp Salud Publica [Internet]. 2024 Jun. 21 [cited 2024 Jul. 25];41(2):178-84. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/13293

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