Obesity as a risk factor in the development of cancer

Authors

  • Deissy Herrera-Covarrubias Centro de Investigaciones Cerebrales. Universidad Veracruzana. Veracruz, Mexico.
  • Genaro Alfonso Coria-Avila Centro de Investigaciones Cerebrales. Universidad Veracruzana. Veracruz, Mexico.
  • Cynthia Fernández-Pomares Centro de Investigaciones Cerebrales. Universidad Veracruzana. Veracruz, Mexico.
  • Gonzalo E. Aranda-Abreu Centro de Investigaciones Cerebrales. Universidad Veracruzana. Veracruz, Mexico.
  • Jorge Manzo Denes Centro de Investigaciones Cerebrales. Universidad Veracruzana. Veracruz, Mexico
  • María Elena Hernández Centro de Investigaciones Cerebrales. Universidad Veracruzana. Veracruz, Mexico.

DOI:

https://doi.org/10.17843/rpmesp.2015.324.1771

Keywords:

Obesity, Cancer, Hormones, Inflammation, Oxidative stress

Abstract

According to the World Health Organization, every year about 3.4 million adults die of consequences related to overweight or obesity. People with a Body Mass Index above 30 are more likely to express certain diseases, including some types of cancer. In this narrative review, we assess the role of adipose tissue as a modulator of the endocrine system and facilitator of chronic subclinical inflammation. We discuss how obesity can induce a suitable micro environment for the development of tumors, mainly by enhancing the levels of oxidative stress and the concentrations of hormones such as leptin, insulin and prolactin. We conclude that all together, these factors increase the probability of cancer development.

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Published

2015-12-06

Issue

Section

Review

How to Cite

1.
Herrera-Covarrubias D, Coria-Avila GA, Fernández-Pomares C, Aranda-Abreu GE, Manzo Denes J, Hernández ME. Obesity as a risk factor in the development of cancer. Rev Peru Med Exp Salud Publica [Internet]. 2015 Dec. 6 [cited 2024 Apr. 23];32(4):766-7. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/1771

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