Estudio farmacoepidemiológico acerca de uso de antiinflamatorios no esteroideos en pacientes de alto riesgo cardiovascular

Jorge Enrique Machado-Alba; Verónica Alzate-Carvajal; Luis Echeverri-Cataño

doi:10.17843/rpmesp.2013.304.243

Authors

Jorge Enrique Machado-Alba Grupo de investigación en Farmacoepidemiología y Fármacovigilancia, Universidad Tecnológica de Pereira. Pereira, Colombia. Audifarma S.A. Pereira, Colombia. Médico, máster en Farmacoepidemiología.
Verónica Alzate-Carvajal Grupo de investigación en Farmacoepidemiología y Fármacovigilancia, Universidad Tecnológica de Pereira. Pereira, Colombia. Audifarma S.A. Pereira, Colombia. estudiante de Medicina.
Luis Echeverri-Cataño Grupo de investigación en Farmacoepidemiología y Fármacovigilancia, Universidad Tecnológica de Pereira. Pereira, Colombia. Audifarma S.A. Pereira, Colombia. médico.

DOI:

https://doi.org/10.17843/rpmesp.2013.304.243

Keywords:

Cardiovascular diseases, Anti-Inflammatory agents, non-steroidal, Pharmacoepidemiology, Pharmacovigilance, Colombia

Abstract

In order to determine the frequency of extended use of non-steroidal anti-inflammatory drugs (NSAID) in Colombian patients with high cardiovascular risk (HCVR), a retrospective study was developed which identified HCVR patients who used NSAID for over five continuous months from January 2011 and March 2013. Patients chronically receiving nitrates, digitalis and clopidogrel and acetylsalicylic acid (ASA), known as HCVR, were identified. An analysis of the frequencies of use based on the co-medication received was performed. Concomitant use of NSAID was found in 0,35% of consumers of nitrates (average time: 9,5 ± 4,4 months), in 0,36% of consumers of clopidogrel and ASA (average time: 9,3 ± 3,4 months), and in 0,4% of consumers of digitalis (10,2 ± 4,6 months). It is concluded that there is a low proportion of chronic use of NSAID in high-risk cardiovascular patients.