Immunological and biochemical response from older adults with urinary tract infection to uropathogenic Escherichia coli virulence factors

Authors

  • Arturo Octavio Gonzales Rodriguez Universidad de Piura, Lima, Perú. Tecnólogo médico en Laboratorio Clínico, bachiller en Tecnología Médica en Laboratorio clínico y Anatomía Patológica https://orcid.org/0000-0002-6377-1596
  • Stefany Fiorella Infante Varillas Universidad de Piura, Lima, Perú. bióloga-microbióloga, magister en Investigación Biomédica
  • Heli Jaime Barrón Pastor Universidad Nacional Mayor de San Marcos, Lima, Perú. tecnólogo médico en Laboratorio Clínico, doctor en Ecología Evolutiva y Genética
  • Yesica Llimpe Mitma Universidad Nacional Mayor de San Marcos, Lima, Perú. biólogo, doctora en Ciencias Biológicas
  • Doris Huerta Canales Universidad Nacional Mayor de San Marcos, Lima, Perú. biólogo, doctora en Ciencias Biológicas
  • Paolo Alberto Wong Chero Universidad de Piura, Lima, Perú. médico cirujano, bachiller en Medicina Humana
  • César Gutierrez Universidad de Piura, Lima, Perú. Médico cirujano, magíster en Epidemiología
  • Silvia Suarez Cunza Universidad Nacional Mayor de San Marcos, Lima, Perú. químico farmacéutico, doctor en Farmacia y Bioquímica.

DOI:

https://doi.org/10.17843/rpmesp.2020.373.4918

Keywords:

Nursing Homes, Elderly, Uropathogenic Escherichia coli, Biomarkers, Virulence Factors, Urinary Tract Infections, Immunology, Urine, Antioxidants, Cytokines

Abstract

Descriptive study in which 24 urine samples from older adults with urinary tract infection (UTI), from nursing homes, were evaluated; in order to identify differences in the immune and biochemical response from older adults with UTI by Escherichia coli (E. coli) to major virulence factors in the pathogenesis of UTI. Iron concentration, TNF-α, IL-1β and antioxidant capacity in urine were determined. A relation was found between, an increase in iron and red blood cell concentration in urine, and the presence of the pap GII gene found in E. coli. It is concluded that older adults, with UTIs by E. coli with the gene pap GII, have increased tissue damage.

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Author Biography

  • Arturo Octavio Gonzales Rodriguez, Universidad de Piura, Lima, Perú. Tecnólogo médico en Laboratorio Clínico, bachiller en Tecnología Médica en Laboratorio clínico y Anatomía Patológica
    Investigador y docente colaborador de la Universidad de Piura.

Published

2020-07-14

Issue

Section

Brief Report

How to Cite

1.
Gonzales Rodriguez AO, Infante Varillas SF, Barrón Pastor HJ, Llimpe Mitma Y, Huerta Canales D, Wong Chero PA, et al. Immunological and biochemical response from older adults with urinary tract infection to uropathogenic Escherichia coli virulence factors. Rev Peru Med Exp Salud Publica [Internet]. 2020 Jul. 14 [cited 2024 May 29];37(3):527-31. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/4918

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