Asociación entre los síntomas de la infección por la COVID-19 y los resultados materno-perinatales adversos en gestantes de un hospital de referencia

Kevyn Angulo-Fernandez; Adrian Olivera-Rojas; Benoit Mougenot; Percy Herrera Añazco

doi:10.17843/rpmesp.2023.401.11205

Authors

Kevyn Angulo-Fernandez Universidad Peruana de Ciencias Aplicadas, Lima, Perú. https://orcid.org/0000-0003-1458-8282
Adrian Olivera-Rojas Universidad Peruana de Ciencias Aplicadas, Lima, Perú. https://orcid.org/0000-0002-2880-9093
Benoit Mougenot Centro de Excelencia en Investigaciones Económicas y Sociales en Salud, Facultad de Ciencias Empresariales, Universidad San Ignacio de Loyola, Lima, Perú https://orcid.org/0000-0001-5956-7659
Percy Herrera Añazco Universidad Peruana de Ciencias Aplicadas https://orcid.org/0000-0003-0282-6634

DOI:

https://doi.org/10.17843/rpmesp.2023.401.11205

Keywords:

COVID-19, SARS-CoV-2, Severity of Illness Index, Pregnancy, Newborn

Abstract

Objectives. To determine the association between symptoms of COVID-19 infection and adverse maternal-perinatal outcomes in pregnant women from a referral hospital. Materials and methods. Analytical cross-sectional study of women in the third trimester of pregnancy hospitalized due to COVID-19 in the gynecology and obstetrics area of a general hospital in Lima during 2020. Clinical and obstetric variables were collected. Fisher’s exact test and Chi-square test were used during the descriptive analysis. Poisson regression was used to find the association between the variables of interest, with a 95% confidence interval (95%CI). Results. A total of 272 pregnant women were included, 50.3% of whom had symptoms of infection. Of these, 35.7% of the pregnant women and 16.5% of the newborns had an adverse outcome. Having symptoms of COVID-19 infection increased the risk of maternal complications as a whole (PR= 2.32 95%CI: 1.61-3.34), premature rupture of membranes (PR= 2.73 95%CI: 1.51-4.94) and preeclampsia (PR= 2.73 95%CI: 1.51-4.94). Similarly, symptoms of COVID-19 infection increased the risk of perinatal complications as a whole (PR= 2.51 95%CI: 1.34-4.68) and acute fetal distress (PR= 2.99 95%CI: 1.07-8.38)]. Conclusions. The presence of symptoms of COVID-19 infection increase the risk of adverse maternal-perinatal outcomes.

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