Invasive fungal infection by Saprochaete Capitata in a child with bone marrow aplasia

Authors

DOI:

https://doi.org/10.17843/rpmesp.2022.393.10955

Keywords:

Invasive Fungal Infections, Mycoses, Fungi, Antifungal Agents, Aplastic Anemia

Abstract

Saprochaete capitata is a rare cause of invasive fungal infection in immunocompromised patients with high mortality and antifungal resistance. We present the case of a 5-year-old boy with bone marrow aplasia, who underwent hematopoietic stem cell transplantation (HSCT) and presented persistent febrile neutropenia, abdominal pain, appearance of maculopapular lesions on the skin, and impaired renal function. The presence of S. capitata was identified by blood culture from a central venous catheter. This invasive
fungal infection is rare but emergent and life-threatening, especially in immunocompromised patients with persistent febrile neutropenia and prolonged use of invasive devices such as central venous catheters.

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References

El Zein S, Hindy JR, Kanj SS. Invasive Saprochaete Infections: An Emerging Threat to Immunocompromised Patients. Pathogens. 2020;9(11):922. doi: 10.3390/pathogens9110922.

Ulu-Kilic A, Atalay MA, Metan G, Cevahir F, Koç N, Eser B, et al. Saprochaete capitata as an emerging fungus among patients with haematological malignencies. Mycoses. 2015;58(8):491-7. doi: 10.1111/myc.12347.

García-Ruiz JC, López-Soria L, Olazábal I, Amutio E, Arrieta-Aguirre I, Velasco-Benito V, et al. Invasive infections caused by Saprochaete capitata in patients with haematological malignancies: report of five cases and review of the antifungal therapy. Rev Iberoam Micol. 2013;30(4):248-55. doi: 10.1016/j.riam.2013.02.004.

Gurgui M, Sanchez F, March F, Lopez-Contreras J, Martino R, Cotura A, et al. Nosocomial outbreak of Blastoschizomyces capitatus associated with contaminated milk in a haematological unit. J Hosp Infect. 2011;78(4):274-8. doi: 10.1016/j.jhin.2011.01.027.

Alobaid K, Abdullah AA, Ahmad S, Joseph L, Khan Z. Magnusiomyces capitatus fungemia: The value of direct microscopy in early diagnosis. Med Mycol Case Rep. 2019;25:32-34. doi: 10.1016/j.mmcr.2019.07.009.

Yilmaz Karapinar D, Karadaş N, Önder Siviş Z, Yazici P, Duyu M, Metin D, et al. Rare severe mycotic infections in children receiving empirical caspofungin treatment for febrile neutropenia. Braz J Infect Dis. 2015;19(5):549-52. doi: 10.1016/j.bjid.2015.06.008.

Sprute R, Cornely OA, Chen SC, Seidel D, Schuetz AN, Zhang SX. All You Need To Know and More about the Diagnosis and Management of Rare Yeast Infections. mBio. 2021:e0159421. doi: 10.1128/mBio.01594-21.

Nobrega de Almeida J, Francisco EC, Holguín Ruiz A, Cuéllar LE, Rodrigues Aquino V, Verena Mendes A, et al. Epidemiology, clinical

aspects, outcomes and prognostic factors associated with Trichosporon fungaemia: results of an international multicentre study carried out at 23 medical centres. J Antimicrob Chemother. 2021;76(7):1907-1915. doi: 10.1093/jac/dkab085.

Maquera-Afaray J, Pérez-Lazo G, Rodriguez R, Illescas R, Rodriguez L, Hidalgo J, et al. Fusariosis invasiva: reporte de tres casos en Perú. Rev Peru Med Exp Salud Publica. 2018;35(3):523-526. doi: 10.17843/rpmesp.2018.353.3175.

Girmenia C, Pagano L, Martino B, D’Antonio D, Fanci R, Specchia G, et al. Invasive infections caused by Trichosporon species and Geotrichum capitatum in patients with hematological malignancies: a retrospective multicenter study from Italy and review of the literature. J Clin Microbiol. 2005;43(4):1818-28. doi: 10.1128/JCM.43.4.1818-1828.2005.

Parahym AM, Rolim Neto PJ, da Silva CM, Domingos Ide F, Gonçalves SS, Leite EP, et al. Invasive infection due to Saprochaete capitata in a young patient with hematological malignancies. Braz J Microbiol. 2015;46(2):527-30. doi: 10.1590/S1517-838246220120447.

Lafayette TC, Oliveira LT, Landell M, Valente P, Alves SH, Pereira WV. Dipodascus capitatus (Geotrichum capitatum): fatal systemic

infection on patient with acute myeloid leukemia. Rev Soc Bras Med Trop. 2011;44(5):648-50. doi: 10.1590/s0037-86822011000500028.

Chen SC, Perfect J, Colombo AL, Cornely OA, Groll AH, Seidel D, et al. Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM. Lancet Infect Dis. 2021;21(12):e375-e386. doi: 10.1016/S1473-3099(21)00203-6.

Schuermans C, van Bergen M, Coorevits L, Verhaegen J, Lagrou K, Surmont I, et al. Breakthrough Saprochaete capitata infections in patients receiving echinocandins: case report and review of the literature. Med Mycol. 2011;49(4):414-8. doi: 10.3109/13693786.2010.535179.

Published

2022-09-30

Issue

Section

Case Report

How to Cite

1.
Maquera-Afaray J, Escajadillo-Vergara C, Chire-Mercado J, Durand MP. Invasive fungal infection by Saprochaete Capitata in a child with bone marrow aplasia. Rev Peru Med Exp Salud Publica [Internet]. 2022 Sep. 30 [cited 2024 Dec. 24];39(3):372-5. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/10955

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