Congenital toxoplasmosis with severe neurological disease in a referral hospital in Peru

Authors

DOI:

https://doi.org/10.17843/rpmesp.2022.392.10897

Keywords:

Congenital Toxoplasmosis, Hydrocephalus, Microcephaly, Chorioretinitis, Central Diabetes Insipidus

Abstract

The aim of this study was to describe the epidemiological, clinical, and therapeutic characteristics of patients diagnosed with congenital toxoplasmosis (CT) with severe neurological disease. We reviewed the medical records of patients under 1 year of age with positive IgM test for Toxoplasma gondii and brain, eye, and/or hearing involvement. This study was carried out at the Instituto Nacional de Salud del Niño San Borja (INSNSB), Lima, Peru. Twenty-one patients diagnosed with CT were evaluated; 57.1% were female, and the median age at diagnosis was 3.1 months (IQR: 1.7-7.3). The main central nervous system manifestations were hydrocephalus (76.2%), intracranial calcifications (52.4%), microcephaly (42.9%),
and convulsions (25.6%); the most frequent ocular manifestation was chorioretinitis (38.1%). In conclusion, 64% of CT cases had one or more manifestations of severe neurological disease.

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Author Biography

  • Julio Maquera-Afaray, Instituto Nacional de Salud del Niño San Borja, Lima, PerúUniversidad Privada de Tacna, Tacna, Perú.Médico infectólogo
       

Published

2022-06-30

Issue

Section

Brief Report

How to Cite

1.
Maquera-Afaray J, Luna-Vilchez M, Salazar-Mesones B, Chiara-Chilet C, Cordero-Campos A, López JW. Congenital toxoplasmosis with severe neurological disease in a referral hospital in Peru. Rev Peru Med Exp Salud Publica [Internet]. 2022 Jun. 30 [cited 2024 Jun. 19];39(2):208-13. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/10897

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