Iron status and a proposal for hemoglobin adjustment by altitude in children 6 to 8 months old living in Lima, Arequipa, Cusco and Puno




Child, Anemia, Altitude, Iron-Deficiency, Peru


Objective. To describe the iron status profile and to propose hemoglobin adjustment factors for altitude for children aged 6 to 8 months in Lima, Arequipa, Cusco and Puno. Materials and methods. Cross-sectional study in children aged 6 to 8 months from four cities. We measured hemoglobin and other iron biomarkers, C-reactive protein (CRP), among others. To estimate the adjustment equation, we applied an exponential regression. We excluded children with iron deficiency (ID) and/or inflammation. Results. The proportions of ID were higher in Puno and Arequipa, while inflammation did not exceed 19% in any of the cities. Hemoglobin showed an exponential increase at higher altitude. The adjustment equation was: 10.34249 x (1.00007 ^ Alt). Conclusions. Children residing in Arequipa and Puno showed higher rates of ID and lower iron reserves; furthermore, the increase in hemoglobin by altitude was exponential, showing the need to adjust hemoglobin at altitude.


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Aparco JP, Santos-Antonio G, Bautista-Olortegui W, Alvis-Chirinos K, Velarde-Delgado P, Hinojosa-Mamani P, et al. Iron status and a proposal for hemoglobin adjustment by altitude in children 6 to 8 months old living in Lima, Arequipa, Cusco and Puno. Rev Peru Med Exp Salud Publica [Internet]. 2023 Dec. 18 [cited 2024 Jun. 18];40(4):395. Available from:

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