Exploratory review on the evidence of Andean crops with hypoglycemic effect and their bioactive components





Hypoglycemic Agents, Nutritional Sciences, Andean Ecosystem, Review, Food


Diabetes is a chronic disease that affects several people around the world. Some domesticated crops in South America have been reported to be a promising source of bioactive compounds with possible hypoglycemic effects. In this review we aimed to explore and synthesize the existing evidence in the scientific
literature on the hypoglycemic effect of Andean crops and their bioactive components. We included different
types of primary studies from three databases (Scopus, Pubmed and Web of Science) during June 2023, without restrictions, by means of controlled and uncontrolled language, according to the PICO strategy. We found 30 studies conducted between 2005 and 2022 that reported a hypoglycemic effect, through enzymatic inhibition in in vitro studies and significant glucose reduction in preclinical studies and clinical trials. This effect was attributed to different bioactive components that were identified with independent mechanisms related to glucose reduction and enzymatic inhibition. The most commonly used cultures were Smallanthus sonchifolius (9/30), Lupinus mutabilis (5/30) and Solanum tuberosum (4/30). The hypoglycemic effect was assigned to bioactive components such as polyphenols, flavonoids, phenolic acid subclasses, fructans, alkaloids, hydrolysates, anthocyanins and dietary fiber. Despite encouraging results from different types of studies, further research on their mechanisms of action, their
efficacy compared to conventional treatments and their long-term safety is required for these to be considered
safe and effective treatments.


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How to Cite

Díaz Núñez D, Rivera-Torres B. Exploratory review on the evidence of Andean crops with hypoglycemic effect and their bioactive components. Rev Peru Med Exp Salud Publica [Internet]. 2023 Dec. 18 [cited 2024 Feb. 28];40(4):474. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/12672

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