Síndrome de fuga capilar por mordedura de serpiente en la Amazonía. Reporte de un caso

Edgar A. Ramírez-García; Arley Perez-Mori; Mónica Mori-Coral; Maria Jose V. Canchanya-Olimar; Juan C. Celis-Salinas; Martín Casapia-Morales

doi:10.17843/rpmesp.2024.414.13614

Authors

Edgar A. Ramírez-García Universidad Nacional de la Amazonia Peruana, Loreto, Perú. Hospital Regional de Loreto, Loreto, Perú https://orcid.org/0000-0002-0881-0839
Arley Perez-Mori Universidad Nacional de la Amazonia Peruana, Loreto, Perú. Sociedad Científica de Estudiantes de Medicina de la Amazonía Peruana, Loreto, Perú https://orcid.org/0000-0002-2783-9485
Mónica Mori-Coral Universidad Nacional de la Amazonia Peruana, Loreto, Perú https://orcid.org/0009-0009-5102-7143
Maria Jose V. Canchanya-Olimar Universidad Nacional de la Amazonia Peruana, Loreto, Perú https://orcid.org/0009-0009-5854-3538
Juan C. Celis-Salinas Hospital Regional de Loreto, Loreto, Perú. https://orcid.org/0000-0003-2086-2313
Martín Casapia-Morales Universidad Nacional de la Amazonia Peruana, Loreto, Perú. Hospital Regional de Loreto, Loreto, Perú https://orcid.org/0000-0002-5972-0948

DOI:

https://doi.org/10.17843/rpmesp.2024.414.13614

Keywords:

Child, Snake Bites, Capillary Leak Syndrome

Abstract

Capillary leak syndrome is a unique complication characterized by extravasation of liquids in the interstitial space due to protein loss caused by snakebite envenoming. We describe the case of a 12-year-old boy from the district of Napo in the city of Iquitos in the Peruvian Amazon, who had edema and increased face volume due to the bite of a snake of the Bothrops genus in the lateral aspect of the right leg; he was the hospitalized and diagnosed with severe ophidism complicated with face edema. The patient received eight vials of antivenin, antibiotics and analgesics. Finally, the patient was discharged from the hospital after eight days of hospitalization, with favorable evolution and recovery.

Downloads

Download data is not yet available.

References

Dheer SK, Lal R, Bhawani RK. A study of clinico-epidemiological profile of patients of snake bite and their outcome in a tertiary care centre in central zone of Himachal Pradesh. Int J Res Med Sci. 2023;11:1192-6. doi: 10.18203/2320-6012.ijrms20230860.

Jayakrishnan MP, Geeta MG, Krishnakumar P, Rajesh TV, George B. Snake bite mortality in children: beyond bite to needle time. Arch Dis Child. 2017;102:445-9. doi: 10.1136/archdischild-2016-311142.

Naik SB. Intravenous Snake Bite: A Catastrophic Snake Envenomation. Ann Afr Med. 2023;22:239-45. doi: 10.4103/aam.aam_9_23.

Willyard C. More People Die From Venomous Snakebites Each Year Than Have Ever Died from Ebola. Nature. 2023;621:S40-7. doi:

1038/d41586-023-02617-2.

Bawaskar HS, Bawaskar PH. Snakebite envenoming. The Lancet. 2019;393:131. doi: 10.1016/S0140-6736(18)32745-4

Centro Nacional de Epidemiologia, Prevención y Control de Enfermedades. Número de casos de ofidismo, Perú 2018 – 2023* [Internet]. 2023 [citado el 5 de diciembre de 2023]. Disponible en: https://www.dge.gob.pe/portal/docs/vigilancia/sala/2023/SE11/ofidismo.pdf.

Gopalakrishnan M, Saurabh S, Sagar P, Bammigatti C, Dutta TK. A simple mortality risk prediction score for viper envenoming in India

(VENOMS): A model development and validation study. PLoS Negl Trop Dis. 2022;16:e0010183. doi: 10.1371/journal.pntd.0010183.

Guile L, Lee A, Gutiérrez JM. Factors associated with mortality after snakebite envenoming in children: a scoping review. Trans R Soc Trop Med Hyg. 2023;117:617-27. doi: 10.1093/trstmh/trad031.

Udayabhaskaran V, Arun Thomas ET, Shaji B. Capillary Leak Syndrome Following Snakebite Envenomation. Indian J Crit Care Med

Peer-Rev Off Publ Indian Soc Crit Care Med. 2017;21:698-702. doi: 10.4103/ijccm.IJCCM_41_17.

Rucavado A, Escalante T, Camacho E, Gutiérrez JM, Fox JW. Systemic vascular leakage induced in mice by Russell’s viper venom from Pakistan. Sci Rep. 2018;8:16088. doi: 10.1016/j.toxicon.2020.07.025.

Kendre PP, Jose MP, Varghese AM, Menon JC, Joseph JK. Capillary leak syndrome in Daboia russelii bite-a complication associated with poor outcome. Trans R Soc Trop Med Hyg. 2018;112:88-93. doi: 10.1093/trstmh/try026.

Lee H yun, Shin J, Kim SH, Hwang JH. Idiopathic systemic capillary leak syndrome: a case report. BMC Nephrol. 2023;24:72. doi:

1186/s12882-023-03122-4.

Varadarajan P, Venugopal GS, Subramaniyan R, Rangabashyam N, Velayutham B. Unusual cause of Capillary leak syndrome with shock in a child. Pediatr Oncall J. 2022;22:1. doi: 10.7199/ped.oncall.2025.1

Lingam TMC, Tan KY, Tan CH. Capillary leak syndrome induced by the venoms of Russell’s Vipers (Daboia russelii and Daboia siamensis) from eight locales and neutralization of the differential toxicity by three snake antivenoms. Comp Biochem Physiol Toxicol Pharmacol CBP. 2021;250:109186. doi: 10.1016/j.cbpc.2021.109186.

Siddall E, Khatri M, Radhakrishnan J. Capillary leak syndrome: etiologies, pathophysiology, and management. Kidney Int. 2017;92:37-46. doi: 10.1016/j.kint.2016.11.029.