Perio­dontitis apical y sus efectos sobre el tejido renal en ratas

Cynthia Mireya Jara; Roccio Raquel Ramírez; Regina Susana Barreto; H´ector García-Salinas; Carlos Gabriel Adorno; Vicente Fretes; Shyrley Paola Amarilla; Clarisse  Díaz-Reissner

doi:10.17843/rpmesp.2014.314.13947

Authors

Cynthia Mireya Jara Universidad Nacional de Asunción, Facultad de Odontología, Asunción, Paraguay https://orcid.org/0000-0002-7345-1529
Roccio Raquel Ramírez Universidad Nacional de Asunción, Facultad de Ciencias Médicas, Asunción, Paraguay https://orcid.org/0009-0008-5938-0673
Regina Susana Barreto Universidad Nacional de Asunción, Facultad de Ciencias Médicas, Asunción, Paraguay https://orcid.org/0000-0001-8909-7870
H´ector García-Salinas Universidad Nacional de Asunción, Facultad de Ciencias Médicas, Asunción, Paraguay https://orcid.org/0000-0003-0332-3633
Carlos Gabriel Adorno Universidad Nacional de Asunción, Facultad de Odontología, Asunción, Paraguay https://orcid.org/0000-0002-7118-2361
Vicente Fretes Universidad Nacional de Asunción, Facultad de Odontología, Asunción, Paraguay https://orcid.org/0000-0003-3457-9017
Shyrley Paola Amarilla Universidad Nacional de Asunción, Facultad de Ciencias Veterinarias, San Lorenzo, Paraguay https://orcid.org/0000-0001-5943-4901
Clarisse Díaz-Reissner Universidad Nacional de Asunción, Facultad de Odontología, Asunción, Paraguay https://orcid.org/0000-0002-7312-1386

DOI:

https://doi.org/10.17843/rpmesp.2014.314.13947

Keywords:

chronic kidney disease, glomerulonephritis, endodontic inflammation, endodontics, blood pressure, Wistar rats, animal models

Abstract

Objetives. To evaluate the effect of apical periodontitis (AP) induced in Wistar rats on histologically examined renal tissue. Materials and methods. Fourteen 12-week-old male Wistar rats weighing an average of 250 grams were used. AP was induced with pulp exposure of the upper and lower first molars using a #1011 HL spherical bur in high rotation. The lesions were left exposed to the oral environment for a period of 7 weeks. Blood pressure was measured by the tail-cuff plethysmography method from the fourth week.
The kidney was dissected for histological analysis (H&E). Mann-Whitney and Student’s t-test were used for non-parametric and parametric data, respectively, with a significance level of 5%. Results. A statistically significant increase in both Bowman’s space area and renal corpuscle area was found in the AP group (p<0.05). The AP group had a higher percentage of renal tissue with inflammatory infiltrate, but without significant difference. Blood pressure did change during the experimental period and no difference was identified between the groups. Conclusions. Induction of AP in Wistar rats resulted in significant changes of certain renal histological parameters, suggesting a possible interaction between AP and renal tissue that requires further research.

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