Apical periodontitis and its effects on renal tissue in rats

Authors

DOI:

https://doi.org/10.17843/rpmesp.2014.314.13947

Keywords:

chronic kidney disease, glomerulonephritis, endodontic inflammation, endodontics, blood pressure, Wistar rats, animal models

Abstract

Objetives. To evaluate the effect of apical periodontitis (AP) induced in Wistar rats on histologically examined renal tissue. Materials and methods. Fourteen 12-week-old male Wistar rats weighing an average of 250 grams were used. AP was induced with pulp exposure of the upper and lower first molars using a #1011 HL spherical bur in high rotation. The lesions were left exposed to the oral environment for a period of 7 weeks. Blood pressure was measured by the tail-cuff plethysmography method from the fourth week.
The kidney was dissected for histological analysis (H&E). Mann-Whitney and Student’s t-test were used for non-parametric and parametric data, respectively, with a significance level of 5%.  Results. A statistically significant increase in both Bowman’s space area and renal corpuscle area was found in the AP group (p<0.05). The AP group had a higher percentage of renal tissue with inflammatory infiltrate, but without significant difference. Blood pressure did change during the experimental period and no difference was identified between the groups. Conclusions. Induction of AP in Wistar rats resulted in significant changes of certain renal histological parameters, suggesting a possible interaction between AP and renal tissue that requires further research.

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Published

2024-11-26

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How to Cite

1.
Jara CM, Ramírez RR, Barreto RS, García-Salinas H, Adorno CG, Fretes V, et al. Apical periodontitis and its effects on renal tissue in rats. Rev Peru Med Exp Salud Publica [Internet]. 2024 Nov. 26 [cited 2024 Dec. 13];41(4):385-91. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/13947