Antiteratogenic capacity of Resveratrol in Streptozotocin-induced diabetes in rats
Keywords:Teratogenesis, Congenital abnormalities, Antioxidants
AbstractObjectives. To evaluate the anti-hyperglycemic and anti-teratogenic capacity of resveratrol in streptozotocin-induced diabetic rats. Material and methods. Experimental study. There were three groups, of five rats each; two groups were treated with a single dose of 50 mg/Kg of streptozotocin (STZ), in citrate buffer, at the 4th day of gestation, and the third group was considered the control, and were administered with citrate buffer only. One of the two STZ induced groups was administered with 100 mg/Kg resveratrol the days 8th to 12th, when neurulation occurs. Fetuses were obtained the 19th gestational day, and were subjected to morphologic analysis; and in fetal liver the activities of scavenging enzymes catalase, superoxide dismutase and gluthathione peroxidase were measured. Results. Resveratrol can decrease the teratogenic effect of STZ-induced diabetes, and scavenging activities were beneficed by the administration of this antioxidant. Conclusion. Resveratrol shown embryoprotective properties mediated by amelioration of oxidative stress produced by maternal hyperglycemia.
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How to Cite
Trejo-González NL, Chirino-Galindo G, Palomar-Morales M. Antiteratogenic capacity of Resveratrol in Streptozotocin-induced diabetes in rats. Rev Peru Med Exp Salud Publica [nternet]. 2015 Sep. 24 [cited 2023 Jun. 1];32(3):457-63. vailable from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/1674