Microsurgical resection of glioblastoma guided with intraoperative fluorescein: a retrospective evaluation

Authors

  • Pamela García-Corrochano Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Carlos A. Castañeda Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Enrique Orrego Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Pedro Deza Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Hugo Heinicke Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Sandro Casavilca Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Miluska Castillo Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • karen Cortez Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Carolina Belmar Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Ketty Dolores Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Claudio Flores Oncosalud, AUNA. Lima, Peru.
  • Luis Ojeda Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.

DOI:

https://doi.org/10.17843/rpmesp.2015.323.1676

Keywords:

Glioblastoma, Fluorescein, Microsurgery, Survival analysis

Abstract

Objectives. To evaluate the influence of the use of sodium fluorescein (FLS-Na) in surgery of glioblastoma (GB) on the degree of tumor resection and survival in patients treated at the National Institute of Neoplastic Diseases. Materials and methods. A total of 238 cases of GB treated between 2008 and 2013 were reviewed and 150 cases of GB who underwent surgical resection with clinicopathological information and adequate follow-up were selected. Results. The mean age was 51 years, 58.7% of the cases presented a Karnofsky score of at least 90. FLS-Na was administered in 80 cases (53.3%) and a subtotal and total resection was obtained in 69 (46%) and 81 (54%) cases, respectively. The group that received FLS-Na obtained higher rates of total resection than the group operated with white light alone (77.5 vs 27.1%, p<0.001). The median overall survival (OS) was higher in the group subject to total compared to subtotal resection (17 vs 7 months, p<0.001). The median OS in those who received FLS-Na was higher than in those who did not (15.0 vs 8 months, p=0.003). Other factors affecting OS were age (p=0.002), the Karnofsky score (p=0.052) and radiation therapy (p=0.016) and chemotherapy (p=0.011). Conclusions. The microsurgical technique with administration of FLS-Na was associated with an increase in the rate of total resection and survival.

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Published

2015-09-24

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Section

Original Article

How to Cite

1.
García-Corrochano P, Castañeda CA, Orrego E, Deza P, Heinicke H, Casavilca S, et al. Microsurgical resection of glioblastoma guided with intraoperative fluorescein: a retrospective evaluation. Rev Peru Med Exp Salud Publica [Internet]. 2015 Sep. 24 [cited 2024 May 27];32(3):471-8. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/1676

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