Microsurgical resection of glioblastoma guided with intraoperative fluorescein: a retrospective evaluation

Authors

  • Pamela García-Corrochano Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Carlos A. Castañeda Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Enrique Orrego Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Pedro Deza Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Hugo Heinicke Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Sandro Casavilca Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Miluska Castillo Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • karen Cortez Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Carolina Belmar Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Ketty Dolores Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.
  • Claudio Flores Oncosalud, AUNA. Lima, Peru.
  • Luis Ojeda Instituto Nacional de Enfermedades Neoplasicas. Lima, Peru.

DOI:

https://doi.org/10.17843/rpmesp.2015.323.1676

Keywords:

Glioblastoma, Fluorescein, Microsurgery, Survival analysis

Abstract

Objectives. To evaluate the influence of the use of sodium fluorescein (FLS-Na) in surgery of glioblastoma (GB) on the degree of tumor resection and survival in patients treated at the National Institute of Neoplastic Diseases. Materials and methods. A total of 238 cases of GB treated between 2008 and 2013 were reviewed and 150 cases of GB who underwent surgical resection with clinicopathological information and adequate follow-up were selected. Results. The mean age was 51 years, 58.7% of the cases presented a Karnofsky score of at least 90. FLS-Na was administered in 80 cases (53.3%) and a subtotal and total resection was obtained in 69 (46%) and 81 (54%) cases, respectively. The group that received FLS-Na obtained higher rates of total resection than the group operated with white light alone (77.5 vs 27.1%, p<0.001). The median overall survival (OS) was higher in the group subject to total compared to subtotal resection (17 vs 7 months, p<0.001). The median OS in those who received FLS-Na was higher than in those who did not (15.0 vs 8 months, p=0.003). Other factors affecting OS were age (p=0.002), the Karnofsky score (p=0.052) and radiation therapy (p=0.016) and chemotherapy (p=0.011). Conclusions. The microsurgical technique with administration of FLS-Na was associated with an increase in the rate of total resection and survival.

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Published

2015-09-24

How to Cite

1.
García-Corrochano P, Castañeda CA, Orrego E, Deza P, Heinicke H, Casavilca S, Castillo M, Cortez karen, Belmar C, Dolores K, Flores C, Ojeda L. Microsurgical resection of glioblastoma guided with intraoperative fluorescein: a retrospective evaluation. Rev Peru Med Exp Salud Publica [nternet]. 2015 Sep. 24 [cited 2023 Jun. 1];32(3):471-8. vailable from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/1676

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