Resistance to ganciclovir in cytomegalovirus infection after heart transplant: case report
DOI:
https://doi.org/10.17843/rpmesp.2018.351.3562Keywords:
Heart transplantation, Pediatría, Virus diseases, Antiviral resistance, Foscarnet, PeruAbstract
Cytomegalovirus infection after a heart transplant is a recurrent medical condition. Its frequency increases when the donors are serum-positive, and the recipients are serum-negative to this virus. In the pediatric population, the infection only develops in a small percentage and the patients rarely present resistance to conventional treatment with ganciclovir and valganciclovir. We presented the first report of a pediatric case of the cytomegalovirus infection resistant to ganciclovir and valganciclovir after a heart transplant in a Peruvian public hospital with an unusual presentation. The resistance to these drugs was evident after 277 days of evolution of the disease considering the non-remission of the symptomatology and the persistence of an elevated viral load. The administration of foscarnet led to a clinical and laboratory improvement until remission of the disease.Downloads
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Published
2018-03-23
Issue
Section
Case Report
How to Cite
1.
Rojas-Contreras C, De la Cruz-Ku G, Vilcarromero S, Villacaqui Ayllon R, Valcarcel-Valdivia B. Resistance to ganciclovir in cytomegalovirus infection after heart transplant: case report. Rev Peru Med Exp Salud Publica [Internet]. 2018 Mar. 23 [cited 2024 Dec. 21];35(1):145-9. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/3562