Optimal cytoreduction in advanced ovarian cancer treated with dose-dense paclitaxel and carboplatin followed by interval surgery at the peruvian national institute of neoplastic diseases

Authors

  • Cindy Alcarraz Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. Médico oncólogo
  • Johana Muñiz Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. médico residente de oncología
  • Luis Mas Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. Médico oncólogo
  • Mivael Olivera Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. Médico oncólogo
  • Zaida Morante Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. Médico oncólogo
  • Manuel Alvarez Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. médico cirujano ginecólogo oncólogo
  • Raul Mantilla Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú. estadístico
  • Jhajaira Araujo Oncosalud, AUNA. Lima, Perú. biólogo
  • Joseph Pinto Oncosalud, AUNA. Lima, Perú. biólogo

DOI:

https://doi.org/10.17843/rpmesp.2018.351.3599

Keywords:

Ovarian neoplasms, Chemotherapy, Neoadjuvant therapy, Cytoreduction surgical procedures, Peru

Abstract

Objectives. To determine the rate of optimal cytoreduction in patients with advanced ovarian cancer who received neoadjuvant chemotherapy with dose-dense carboplatin and paclitaxel followed by interval debulking surgery (IDS). Materials and Methods. A retrospective study of a series of cases of Peruvian women treated with neoadjuvant chemotherapy with carboplatin (6 AUC mg/mL/min) and paclitaxel (80 mg/m2 weekly) followed by IDS, at the National Institute of Neoplastic Diseases during the 2010-2014 period. Results. The 41 patients who made it to the interval surgery had a median age of 59 years (range: 47-73 years). In 37 (90.2%) patients, high-grade serous adenocarcinoma histology was reported. Thirty-four (82.9%) achieved optimal cytoreduction and five (14.7%), a complete pathological response. Progression-free survival at one year and two years was 74.7% and 51.8%, respectively. Overall survival at one year and two years was 85.2% and 71.4%, respectively. The risk of progression and death was greater in patients without optimal cytoreduction and in patients with postsurgery levels of carcinoembryonic antigen 125 > 30 U/mL. Conclusions. Neoadjuvant therapy with dose-dense carboplatin and paclitaxel achieved an elevated frequency of optimal cytoreduction. The post-surgery levels of carcinoembryonic antigen 125 and optimal cytoreduction were independent factors of progression-free survival and overall survival.

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Published

2018-04-05

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Section

Original Article

How to Cite

1.
Alcarraz C, Muñiz J, Mas L, Olivera M, Morante Z, Alvarez M, et al. Optimal cytoreduction in advanced ovarian cancer treated with dose-dense paclitaxel and carboplatin followed by interval surgery at the peruvian national institute of neoplastic diseases. Rev Peru Med Exp Salud Publica [Internet]. 2018 Apr. 5 [cited 2024 Mar. 28];35(1):46-54. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/3599

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