Factors associated with survival at one year of life in neonates with severe congenital cardiopathy in a national hospital in Peru

Authors

  • Camilo E. Torres-Romucho Facultad de Medicina, Universidad Nacional San Luis Gonzaga. Ica, Perú. Médico cirujano http://orcid.org/0000-0003-2692-0596
  • Victor G. Uriondo-Oré Facultad de Medicina, Universidad Nacional San Luis Gonzaga. Ica, Perú. Hospital Nacional Alberto Sabogal Sologuren. Lima, Perú. Médico cirujano
  • Alberto J. Ramirez-Palomino Facultad de Medicina, Universidad Nacional San Luis Gonzaga. Ica, Perú. Hospital Regional de Ica. Ica, Perú. Médico cirujano
  • Hugo Arroyo-Hernández Oficina General de Información y Sistemas, Instituto Nacional de Salud. Lima, Perú. Médico cirujano http://orcid.org/0000-0001-5128-7820
  • Maria Loo-Valverde Unidad de Cardiopediatría, Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú. Universidad Ricardo Palma. Lima, Perú. médico especialista en Cardiología Infantil
  • Ana Protzel-Pinedo Servicio de Genética, Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú. médico especialista en Genética Médica
  • Milagros Dueñas-Roque Servicio de Genética, Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú. Estudio Colaborativo Latinoamericano de Malformaciones Congénitas (ECLAMC). médico especialista en Genética Médica

DOI:

https://doi.org/10.17843/rpmesp.2019.363.4166

Keywords:

Heart diseases, Congenital, Mortality, Survival, Infant mortality, Perú

Abstract

Objectives. To determine factors associated with survival in the first year of life in neonates with severe congenital heart disease treated in a national hospital in Peru. Materials and Methods. 160 children born between 2012 and 2015 with a diagnosis of severe congenital cardiopathy were studied and admitted to the Neonatology Service of the Edgardo Rebagliati Martins National Hospital of the Peruvian Social Security. The Kaplan-Meier method and the Log-Rank test were used in the survival analysis. Crude and adjusted analyses were performed using Cox regression models. Results. Fifty-two, point 5 percent (52.5%) of patients were male and the most frequent severe congenital cardiopathy was pulmonary atresia (26.3%). Thirty-three, point seven percent (33.7%) of patients died, with a 66.3% (IC95% 58.4-73.0) one-year survival. Prenatal diagnosis improved survival (HRa 0.54, 95% CI 0.30-0.98) while cyanotic cardiopathies (HRa 2.93, 95% CI 1.36-6.34) and the presence of another congenital anomaly (HRa 3.28, 95% CI 1.79-6.01) decreased it; these factors were also significant in a second model stratified by surgical treatment with the exception of the stratified model by complications where a prenatal diagnosis ceased to be significant. Conclusions. Prenatal diagnosis increases survival from severe congenital heart disease. However, cyanotic heart diseases and other congenital anomalies, which decrease this chance, should be considered, if surgery is performed or complications occur.

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Published

2019-09-23

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Section

Original Article

How to Cite

1.
Torres-Romucho CE, Uriondo-Oré VG, Ramirez-Palomino AJ, Arroyo-Hernández H, Loo-Valverde M, Protzel-Pinedo A, et al. Factors associated with survival at one year of life in neonates with severe congenital cardiopathy in a national hospital in Peru. Rev Peru Med Exp Salud Publica [Internet]. 2019 Sep. 23 [cited 2024 Apr. 16];36(3):433-41. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/4166

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