Submicroscopic placental malaria: histopathology and expression of physiological process mediators

Authors

  • Carolina López-Guzmán Grupo Salud y Comunidad-César Uribe Piedrahíta, Universidad de Antioquia, Medellín, Colombia. Bacterióloga; maestra en Ciencias Básicas Biomédicas
  • Jaime Carmona-Fonseca Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia. Médico cirujano; maestro en Microbiología

DOI:

https://doi.org/10.17843/rpmesp.2020.372.4759

Keywords:

Malaria, Plasmodium, Placenta, Histopathology, Pathology, Mediator, Colombia

Abstract

Objetives: To relate histopathological events of placental malaria (PM), immune cell behavior and gene expression associated with cytokines, hypoxia, inflammation and angiogenesis in placentas with or without plasmodial infection. Materials and methods: Transversal design, with three independent groups. Women were recruited, and their placentas were collected in 2009-2016, in the hospitals of Puerto Libertador and Tierralta, northwestern Colombia. The sample size was defined by convenience. The malaria diagnosis was based on real-time quantitative PCR. Results: We studied 20 cases of PM by P. vivax (PM-V), 20 cases of PM by P. falciparum (PM-F) and 19 without PM; 95% of the cases of PM are submicroscopic placental plasmodial infection (SPPI). The three groups differ in frequency and number of histopathological events. Physiological process mediators showed significant difference between groups, except IL-2, VEGF, VEGFR-1 and C5a. Conclusions: Infected placentas are clearly different from uninfected ones. P. vivax behaves as pathogenic as P. falciparum. The approximation to the integral approach of the problem of PM is underlined. Submicroscopic placental plasmodial infection causes tissue and physiological mediator alterations as does microscopic infection, although probably to a lesser degree.

Downloads

Download data is not yet available.

Author Biography

  • Jaime Carmona-Fonseca, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia. Médico cirujano; maestro en Microbiología

    Profesor titular

    Departamento de Microbiología y Parasitología

    Facultad de Medicina

Published

2020-02-26

Issue

Section

Original Article

How to Cite

1.
López-Guzmán C, Carmona-Fonseca J. Submicroscopic placental malaria: histopathology and expression of physiological process mediators. Rev Peru Med Exp Salud Publica [Internet]. 2020 Feb. 26 [cited 2024 Jun. 13];37(2):220-8. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/4759

Most read articles by the same author(s)