Synthesis studies as the basis for economic evaluations in health: the need for their quality appraisal

Authors

  • Rafael Bolaños-Díaz Unidad de Análisis y Generación de Evidencias en Salud Pública, Centro Nacional de Salud Pública, Instituto Nacional de Salud. Lima, Perú. Escuela de Postgrado, Universidad Nacional Mayor de San Marcos. Lima, Perú. Médico especialista en Medicina Interna, Magíster en Epidemiología Clínica, Magíster en Economía de la Salud.
  • Edward Mezones-Holguín Unidad de Análisis y Generación de Evidencias en Salud Pública, Centro Nacional de Salud Pública, Instituto Nacional de Salud. Lima, Perú. Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú. Médico Cirujano, Magíster en Epidemiología Clínica.
  • Alfonso Gutiérrez-Aguado Unidad de Análisis y Generación de Evidencias en Salud Pública, Centro Nacional de Salud Pública, Instituto Nacional de Salud. Lima, Perú. Facultad de Ciencias Médicas, Universidad César Vallejo, Lima - Norte. Lima, Perú. Médico Especialista en Gestión en Salud.
  • Germán Málaga Centro De Excelencia CRONICAS, Universidad Peruana Cayetano Heredia. Lima, Perú. Médico especialista en Medicina Interna, Doctor en Medicina.

DOI:

https://doi.org/10.17843/rpmesp.2011.283.534

Keywords:

Reviews, Meta-analysis as topic, Evidence-based practice, Health Research research evaluation, Health economics

Abstract

Synthesis studies (SS): systematic review and meta-analysis are the basis for developing Health Economic Evaluations (HEE). SS allow us to obtain parameters for estimating probabilities and effectiveness from the combination of the results of primary studies, and, as they include in their methodology the selection, evaluation, systematization and synthesis processes, they are considered the first level of hierarchy in scientific evidence. Nevertheless, they can be prone to bias and methodological failures that can affect the validity of their results. This article initially presents the relevance of the randomization in the hierarchic classification of research designs, then it reviews the main factors affecting the validity of the SS, emphasising the publication bias, the heterogeneity and the inclusion of primary studies with main objective differing from the one of the SS. Moreover, it presents individual studies like a valid alternative for the development of a SS. The conclusion is that one of the key aspects in a SS is the correct evaluation of the study types and the objective evaluation of their quality, being these primary or secondary.

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Published

2011-09-30

Issue

Section

Symposium

How to Cite

1.
Bolaños-Díaz R, Mezones-Holguín E, Gutiérrez-Aguado A, Málaga G. Synthesis studies as the basis for economic evaluations in health: the need for their quality appraisal. Rev Peru Med Exp Salud Publica [Internet]. 2011 Sep. 30 [cited 2024 Jun. 23];28(3). Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/534

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