Características clínicas y respuesta al recambio plasmático terapéutico en los pacientes con síndrome de Guillain Barré

Erik Guevara-Silva; Sheila Castro-Suarez; César Caparó-Zamalloa; Jaqueline Cortez-Escalante; María Meza-Vega

doi:10.17843/rpmesp.2021.381.6233

Authors

Erik Guevara-Silva Centro de Investigación Básica en Demencias y Enfermedades Desmielinizantes del Sistema Nervioso, Instituto Nacional de Ciencias Neurológicas, Lima, Perú. Médico especialista en Neurología; doctor en Medicina http://orcid.org/0000-0002-1106-5024
Sheila Castro-Suarez Centro de Investigación Básica en Demencias y Enfermedades Desmielinizantes del Sistema Nervioso, Instituto Nacional de Ciencias Neurológicas, Lima, Perú. Atlantic Fellow for Equity in Brain Health at the University of California San Francisco, Department of Neurology, University of California San Francisco, CA, USA. Médico especialista en Neurología http://orcid.org/0000-0003-0313-3987
César Caparó-Zamalloa Centro de Investigación Básica en Demencias y Enfermedades Desmielinizantes del Sistema Nervioso, Instituto Nacional de Ciencias Neurológicas, Lima, Perú. Médico especialista en Neurología http://orcid.org/0000-0002-6896-3052
Jaqueline Cortez-Escalante Centro de Investigación Básica en Demencias y Enfermedades Desmielinizantes del Sistema Nervioso, Instituto Nacional de Ciencias Neurológicas, Lima, Perú. Médico especialista en Neurología http://orcid.org/0000-0002-8957-059X
María Meza-Vega Centro de Investigación Básica en Demencias y Enfermedades Desmielinizantes del Sistema Nervioso, Instituto Nacional de Ciencias Neurológicas, Lima, Perú. Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. Médico especialista en Neurología magister en Neuropsicología http://orcid.org/0000-0003-4166-6944

DOI:

https://doi.org/10.17843/rpmesp.2021.381.6233

Keywords:

Cerebrospinal Fluid, Axonal Neuropathy, Demyelinating Neuropathy, Poliradiculoneuropathy, Plasmapheresis, Peru, Plasmatic Therapeutic Exchange, Guillain-Barré Syndrome

Abstract

The objective of the study was to describe the clinical characteristics, treatment response and possible associated factors of patients with Guillain-Barré syndrome at the National Institute of Neurological Sciences. A descriptive study on hospital discharges was conducted during the period 2017-2019. Treatment response was evaluated based on Hughes’ disability scale. From 31 patients 61.3% were males and the mean age was 50 years. At admission, 87.1% of patients were on grade 3 or 4 of Hughes scale, most of them with axonal compromise which was associated to disability. Only 22 patients received plasma exchange; 6 months thereafter, 90.9% of patients decreased by at least one degree in Hughes scale and 42.8% were left without disability. In conclusion, a male and axonal subtype predominance was found, been the latter associated to disability.