Identificación de células proliferativas en quistes de Taenia solium

Miguel Ángel Orrego-Solano; Carla Cangalaya; Theodore E. Nash; Cristina Guerra-Giraldez

doi:10.17843/rpmesp.2014.314.121

Authors

Miguel Ángel Orrego-Solano Laboratorio de Inmunopatología en Neurocisticercosis, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia. Lima, Perú.
Carla Cangalaya Laboratorio de Inmunopatología en Neurocisticercosis, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia. Lima, Perú.
Theodore E. Nash Laboratorio de Inmunopatología en Neurocisticercosis, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia. Lima, Perú. Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health. Bethesda, Maryland, EE. UU.
Cristina Guerra-Giraldez Laboratorio de Inmunopatología en Neurocisticercosis, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia. Lima, Perú. Departamento de Ciencias Celulares y Moleculares, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia. Lima, Perú.

DOI:

https://doi.org/10.17843/rpmesp.2014.314.121

Keywords:

Parasitology, Taenia solium, In vitro, Cell proliferation

Abstract

Neoblasts are totipotent cells, solely responsible for the proliferation and maturation of tissues in free-living flatworms. Similar cells have been isolated from parasitic flatworms such as Echinococcus. Taenia solium causes human taeniasis (intestinal) and cysticercosis in humans and pigs. Brain infection with larvae (cysts) of T. solium results in neurocysticercosis which is hyperendemic in Peru, and its treatment is associated with serious neurological symptoms. The proliferative capacity and development stages of T. solium have not been described and the neoblasts of this parasite have not been characterized We looked for cell proliferation in T. solium cysts collected from an infected pig, which were identified when replicating and incorporating bromodeoxyuridine nucleotide detected with a monoclonal antibody. A stable cell line of neoblasts would be useful for systematic in vitro studies on drug efficacy and the biology of T. solium.