Antiteratogenic capacity of Resveratrol in Streptozotocin-induced diabetes in rats

Authors

  • Ninna Leslie Trejo-González Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de Mexico. Estado de Mexico, Mexico.
  • Gladys Chirino-Galindo Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico. Estado de Mexico, Mexico.
  • Martín Palomar-Morales Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico. Estado de Mexico, Mexico.

DOI:

https://doi.org/10.17843/rpmesp.2015.323.1674

Keywords:

Teratogenesis, Congenital abnormalities, Antioxidants

Abstract

Objectives. To evaluate the anti-hyperglycemic and anti-teratogenic capacity of resveratrol in streptozotocin-induced diabetic rats. Material and methods. Experimental study. There were three groups, of five rats each; two groups were treated with a single dose of 50 mg/Kg of streptozotocin (STZ), in citrate buffer, at the 4th day of gestation, and the third group was considered the control, and were administered with citrate buffer only. One of the two STZ induced groups was administered with 100 mg/Kg resveratrol the days 8th to 12th, when neurulation occurs. Fetuses were obtained the 19th gestational day, and were subjected to morphologic analysis; and in fetal liver the activities of scavenging enzymes catalase, superoxide dismutase and gluthathione peroxidase were measured. Results. Resveratrol can decrease the teratogenic effect of STZ-induced diabetes, and scavenging activities were beneficed by the administration of this antioxidant. Conclusion. Resveratrol shown embryoprotective properties mediated by amelioration of oxidative stress produced by maternal hyperglycemia.

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Published

2015-09-24

Issue

Section

Original Article

How to Cite

1.
Trejo-González NL, Chirino-Galindo G, Palomar-Morales M. Antiteratogenic capacity of Resveratrol in Streptozotocin-induced diabetes in rats. Rev Peru Med Exp Salud Publica [Internet]. 2015 Sep. 24 [cited 2024 Mar. 29];32(3):457-63. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/1674

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