Medication use in pediatric patients with COVID-19 hospitalized in a referral hospital in Lima, Peru, 2020 - 2022

Authors

DOI:

https://doi.org/10.17843/rpmesp.2023.401.12326

Keywords:

COVID-19, children, drugs, Peru

Abstract

This study aimed to describe the use of medication in pediatric patients with COVID-19 hospitalized at the National Children’s Health Institute - San Borja (INSN-SB) in Lima, Peru, between March 2020 and March 2022. Therefore, we conducted a descriptive, observational study to evaluate the use of six medications: corticosteroids, ceftriaxone, azithromycin, immunoglobulin, hydroxychloroquine, and ivermectin. We compared the results among subpopulations defined according to the COVID-19 pandemic waves. We included 421 pediatric patients. Corticosteroids were prescribed to 40.4%, ceftriaxone to 35.6%, azithromycin to 12.1%, immunoglobulin to 3.6%, hydroxychloroquine to 2.4%, and ivermectin to 0.5% of the patients. The use of ceftriaxone and azithromycin was less frequent during the third wave. Hydroxychloroquine was used almost exclusively during the first wave. Only patients with pediatric multisystem inflammatory syndrome used immunoglobulin. Overall, the prescription of the evaluated medications
decreased during the third wave.

Downloads

Download data is not yet available.

References

Bajwah S, Wilcock A, Towers R, Costantini M, Bausewein C, Simon ST, et al. Managing the supportive care needs of those

affected by COVID-19. Eur Respir J. 2020;55(4):2000815. doi:10.1183/13993003.00815-2020.

Castro NE, García DR, Rivera MT, Rondán-Guerrero P, García-Rojas F, Taype-Rondan A, et al. Tendencias en el uso de fármacos para la

COVID-19 durante la primera ola de la pandemia en un hospital de Lima, Perú. Rev Peru Med Exp Salud Publica. 2021;38(4):608–14.

doi:10.17843/rpmesp.2021.384.8820.

Naushad VA, Purayil NK, Chandra P, Saeed AAM, Radhakrishnan P, Varikkodan I, et al. Comparison of demographic, clinical and laboratory characteristics between first and second COVID-19 waves in a secondary care hospital in Qatar: a retrospective study. BMJ Open. 2022;12(6):e061610. doi:10.1136/bmjopen-2022-061610.

Ministerio de Salud del Perú. Resolución Ministerial N° 193-2020-MINSA [Internet]. 2022 [citado el 16 de agosto de 2022].

Disponible en: https://www.gob.pe/institucion/minsa/normas-legales/473575-193-2020-minsa.

Ministerio de Salud del Perú. Resolución Ministerial N° 839-2020-MINSA [Internet]. 2022 [citado el 16 de agosto de 2022].

Disponible en: https://www.gob.pe/institucion/minsa/normas-legales/1264399-839-2020-minsa.

Ministerio de Salud del Perú. Resolución Ministerial N° 282-2022-MINSA [Internet]. [citado el 23 de agosto de 2022].

Disponible en: https://www.gob.pe/institucion/minsa/normas-legales/2890800-282-2022-minsa.

Instituto de Evaluación de Tecnologías en Salud e Investigación - EsSalud. Guía de práctica clínica COVID-19 en niños [Enero 2022]

[Internet]. 2022 [citado el 23 de agosto de 2022]. Disponible en: https://www.gpc-peru.com/gpccovidpediatria.

Panda PK, Sharawat IK, Natarajan V, Bhakat R, Panda P, Dawman L. COVID-19 treatment in children: A systematic review and meta-analysis. J Fam Med Prim Care. 2021;10(9):3292–302. doi: 10.4103/jfmpc.jfmpc_2583_20.

Domínguez Rojas J, Estupiñan Vigil M, Garcés-Ghilardi R, Alvarado-Gamarra G, Del Águila O, Lope Tenorio AF, et al. Estudio

transversal analítico de las características y desenlaces clínicos de niños hospitalizados con COVID-19 en Lima, Perú. Medwave.

;21(1):e8107. doi: 10.5867/medwave.2021.01.8107.

Instituto Nacional de Salud del Niño - San Borja. Guía Técnica para el Diagnóstico y Tratamiento de Covid-19 en Pediatría [Internet]. 2020 [citado el 23 de agosto de 2022]. Disponible en: https://www.insnsb.gob.pe/docs-web/Covid/RD073.pdf.

World Health Organization. Living guidance for clinical management of COVID-19 [Internet]. 2021 [citado el 20 de setiembre del 2022]. Disponible en: https://www.who.int/publications/i/item/WHO-2019-nCoV-clinical-2021-2.

Vishwa C.R., Sharma R, Jayashree M, Nallasamy K, Bansal A, Angurana SK, et al. Epidemiology, Clinical Profile, Intensive Care Needs and Outcome in Children with SARS-CoV-2 Infection Admitted to a Tertiary Hospital During the First and Second Waves of the COVID-19 Pandemic in India. Indian J Pediatr. 2022;1–8. doi:10.1007/s12098-022-04283-0.

Götzinger F, Santiago-García B, Noguera-Julián A, Lanaspa M, Lancella L, Carducci FIC, et al. COVID-19 in children and adolescents in

Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health. 2020;4(9):653–61. doi: 10.1016/S2352-4642(20)30177-2.

Turan C, Gökçe Basa E, Elitez D, Yılmaz Ö, Gümüş E, Anıl M. The Comparison of Children Who Were Diagnosed with COVID-19 in the First and the Second Waves of the SARS-CoV-2 Pandemic. Turk Arch Pediatr. 2021;56(6):596–601. doi:10.5152/TurkArchPediatr.2021.21162.

Lansbury L, Lim B, Baskaran V, Lim WS. Co-infections in people with COVID-19: a systematic review and meta-analysis. J Infect.

;81(2):266–75. doi: 10.1016/j.jinf.2020.05.046.

Aguilera-Alonso D, Epalza C, Sanz-Santaeufemia FJ, Grasa C, Villanueva-Medina S, Melendo Pérez S, et al. Antibiotic Prescribing in Children Hospitalized With COVID-19 and Multisystem Inflammatory Syndrome in Spain: Prevalence, Trends, and Associated Factors. J

Pediatr Infect Dis Soc. 2022;piac003. doi:10.1093/jpids/piac003.

Quincho-Lopez A, Chávez-Rimache L, Montes-Alvis J, Taype-Rondan A, Alvarado-Gamarra G. Characteristics and conflicting recommendations of clinical practice guidelines for COVID-19 management in children: A scoping review. Travel Med Infect Dis. 2022;48:102354. doi: 10.1016/j.tmaid.2022.102354.

Diaz-Arocutipa C, Brañez-Condorena A, Hernandez AV. QTc prolongation in COVID-19 patients treated with hydroxychloroquine, chloroquine, azithromycin, or lopinavir/ritonavir: A systematic review and meta-analysis. Pharmacoepidemiol Drug Saf. 2021;30(6):694–706. doi: 10.1002/pds.5234.

Published

2023-03-31

Issue

Section

Brief Report

How to Cite

1.
Luna-Vilchez M, Mejia JR, Ortiz-Benique ZN, Santiago-Abal M, Taype-Rondan A. Medication use in pediatric patients with COVID-19 hospitalized in a referral hospital in Lima, Peru, 2020 - 2022. Rev Peru Med Exp Salud Publica [Internet]. 2023 Mar. 31 [cited 2024 Nov. 21];40(1):73-8. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/12326

Most read articles by the same author(s)

1 2 > >>