Diagnostic performance of a point-of-care molecular system for the detection of SARS-CoV-2 in Peru

Authors

DOI:

https://doi.org/10.17843/rpmesp.2024.411.13046

Keywords:

SARS-CoV-2, COVID-19, Molecular Diagnostic Techniques, PCR, Sensitivity and Specificity, Peru

Abstract

The present study assessed the diagnostic performance of the Xpert®Xpress SARS-CoV-2 test in comparison with the Charité protocol real-time RT PCR for the detection of SARS-CoV-2 in Peruvian patients. This was a diagnostic test study that included 100 nasal and pharyngeal swab samples. We obtained an overall concordance of 98.70% (95%CI: 92.98-99.97), with a kappa coefficient of 0.97 (95%CI: 0.86-1.00) and sensitivity and relative specificity rates of 100% and 96.15%, respectively. Additionally, the percentage of the area under the ROC curve was 98.08% in both cases, and an analytical specificity rate of 100% was obtained for the different respiratory viruses evaluated. In conclusion, the Xpert®Xpress SARS-CoV-2 test, by using nasal and pharyngeal swab samples, was highly sensitive and specific, and the kappa coefficient showed an excellent correlation when compared to the reference test.

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Published

2024-03-26

Issue

Section

Brief Report

How to Cite

1.
Puyén ZM, Araujo-Castillo R, Giraldo J, Gutierrez K, Rojas-Serrano N. Diagnostic performance of a point-of-care molecular system for the detection of SARS-CoV-2 in Peru. Rev Peru Med Exp Salud Publica [Internet]. 2024 Mar. 26 [cited 2024 Apr. 24];41(1):76-82. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/13046

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