Cáncer de mama en el norte del Perú: subtipos moleculares y HER2 low

Katherine Gómez-Rázuri; Milagros Abad-Licham; Juan Astigueta; Joan Moreno

doi:10.17843/rpmesp.2024.411.13424

Authors

Katherine Gómez-Rázuri Instituto Regional de Enfermedades Neoplásicas del Norte. La Libertad, Perú. https://orcid.org/0000-0002-9097-0224
Milagros Abad-Licham Instituto Regional de Enfermedades Neoplásicas del Norte. La Libertad, Perú. Escuela de Medicina Humana, Universidad Privada Antenor Orrego. La Libertad, Perú. https://orcid.org/0000-0002-3530-6937
Juan Astigueta Instituto Regional de Enfermedades Neoplásicas del Norte. La Libertad, Perú. Escuela de Medicina Humana, Universidad Privada Antenor Orrego. La Libertad, Perú. https://orcid.org/0000-0001-5984-3270
Joan Moreno Instituto Regional de Enfermedades Neoplásicas del Norte. La Libertad, Perú. https://orcid.org/0000-0003-2621-7198

DOI:

https://doi.org/10.17843/rpmesp.2024.411.13424

Keywords:

Breast Neoplasms, inmunohistochemistry, receptor ErbB-2, biomarkers tumor

Abstract

This study aimed to understand the immunohistochemical profile of breast cancer and to identify the HER2 low subgroup in the northern macro-region of Peru. A cross-sectional study was conducted in
1176 patients from the Regional Institute of Neoplastic Diseases Northern Peru, from January 2016 to December 2023. We analyzed the data (age, histological type, grade and complementary results), with frequencies and percentages. The profile corresponded to: luminal B (45.6%); luminal A (24.7%); triple negative (18.2%); and HER2 positive non luminal (11.5%). In addition, 215 patients presented HER2 low (25.1% of those previously considered negative). This study provides evidence that the subtyping of breast cancer has changed, being luminal B the most frequent. It is essential to involve health policies to acquire targeted therapies considering HER2 low patients.

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